UNIGE document Scientific Article
previous document  unige:47541  next document
add to browser collection

Preoperative lipid control with simvastatin reduces the risk for graft failure already 1 year after myocardial revascularization

Published in Cardiovascular Surgery. 2001, vol. 9, no. 1, p. 33-43
Abstract Hypercholesterolemia is a recognized risk factor for development of atherosclerosis in both native coronary arteries and bypass grafts. Lipid-lowering therapy with statins is effective. Few data are available for studies on bypass grafts. The influence of hypercholesterolemia on development of bypass graft disease was studied. Clinical and angiographic follow up 1yr after CABG of patients with a preoperative cholesterol >6.2mmol/l, with a preoperative lipid control (group 2) or controls (group 1) and patients with cholesterol <4.7mmol/l (group 3) were studied. Patient demographics, angiography and operation data were the same in all the groups. Group 1 patients had significantly higher incidence of graft lesions, requiring more interventions than Group 2. Sequential vein bypass grafts showed superior features compared to single vein grafts. Preoperative lipid control with statins is strongly recommended, since uncontrolled hypercholesterolemia has a direct impact on the outcome of CABG procedure. It significantly reduces the development of vein graft obstructive disease.
Keywords FemaleFollow-Up StudiesGraft Rejection/prevention & controlHumansHypercholesterolemia/drug therapyHypolipidemic Agents/therapeutic useMaleMiddle AgedMyocardial RevascularizationPreoperative CareProspective StudiesRisk FactorsSimvastatin/therapeutic useTime Factors
PMID: 11137806
Full text
Article (Published version) (115 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Chirurgie cardio-vasculaire (105)
(ISO format)
CHRISTENSON, Jan. Preoperative lipid control with simvastatin reduces the risk for graft failure already 1 year after myocardial revascularization. In: Cardiovascular Surgery, 2001, vol. 9, n° 1, p. 33-43. doi: 10.1016/S0967-2109(00)00088-0 https://archive-ouverte.unige.ch/unige:47541

315 hits

0 download


Deposited on : 2015-03-04

Export document
Format :
Citation style :