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Title

Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation
Authors
Cretin, Nathalie
Caulfield, A
Fournier, Béatrice
Buehler, Leo Hans
Becker, Christoph
Philippe, Jacques
Morel, Philippe
Published in Transplant International. 2001, vol. 14, no. 5, p. 343-5
Abstract To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin-producing beta-cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long-term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin-independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.
Keywords Adult — Blood Glucose/drug effects/metabolism — C-Peptide/blood — Diabetes Mellitus, Type 1/blood/surgery — Female — Follow-Up Studies — Glucagon/diagnostic use — Glucose Tolerance Test — Humans — Hypoglycemic Agents/therapeutic use — Insulin/therapeutic use — Islets of Langerhans Transplantation/physiology — Reference Values — Time Factors — Transplantation, Homologous
Identifiers
PMID: 11692219
Full text
Article (Published version) (514 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups Chirurgie viscérale (104)
Cultures cellulaires et transplantations (519)
Diabète et régulation des gènes (36)
Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
Citation
(ISO format) 		CRETIN, Nathalie et al. Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation. In: Transplant International, 2001, vol. 14, n° 5, p. 343-5. doi: 10.1111/j.1432-2277.2001.tb00069.x https://archive-ouverte.unige.ch/unige:47538

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Deposited on : 2015-03-04

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