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Title

Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation

Authors
Caulfield, A
Published in Transplant International. 2001, vol. 14, no. 5, p. 343-5
Abstract To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin-producing beta-cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long-term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin-independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.
Keywords AdultBlood Glucose/drug effects/metabolismC-Peptide/bloodDiabetes Mellitus, Type 1/blood/surgeryFemaleFollow-Up StudiesGlucagon/diagnostic useGlucose Tolerance TestHumansHypoglycemic Agents/therapeutic useInsulin/therapeutic useIslets of Langerhans Transplantation/physiologyReference ValuesTime FactorsTransplantation, Homologous
Identifiers
PMID: 11692219
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Article (Published version) (514 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie viscérale (104)
Cultures cellulaires et transplantations (519)
Diabète et régulation des gènes (36)
Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
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(ISO format)
CRETIN, Nathalie et al. Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation. In: Transplant International, 2001, vol. 14, n° 5, p. 343-5. https://archive-ouverte.unige.ch/unige:47538

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Deposited on : 2015-03-04

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