Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation

Cretin, Nathalie; Caulfield, A; Fournier, Béatrice; Buehler, Leo Hans; Becker, Christoph; Philippe, Jacques; Morel, Philippe

doi:10.1111/j.1432-2277.2001.tb00069.x

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Title		Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation
Authors		Cretin, Nathalie Caulfield, A Fournier, Béatrice Buehler, Leo Hans Becker, Christoph Philippe, Jacques Morel, Philippe
Published in		Transplant International. 2001, vol. 14, no. 5, p. 343-5
Abstract		To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin-producing beta-cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long-term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin-independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.
Keywords		Adult — Blood Glucose/drug effects/metabolism — C-Peptide/blood — Diabetes Mellitus, Type 1/blood/surgery — Female — Follow-Up Studies — Glucagon/diagnostic use — Glucose Tolerance Test — Humans — Hypoglycemic Agents/therapeutic use — Insulin/therapeutic use — Islets of Langerhans Transplantation/physiology — Reference Values — Time Factors — Transplantation, Homologous
Identifiers		DOI: 10.1111/j.1432-2277.2001.tb00069.x PMID: 11692219
Full text		Article (Published version) (514 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Cultures cellulaires et transplantations (519) Diabète et régulation des gènes (36) Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
Citation (ISO format)		CRETIN, Nathalie et al. Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation. In: Transplant International, 2001, vol. 14, n° 5, p. 343-5. doi: 10.1111/j.1432-2277.2001.tb00069.x https://archive-ouverte.unige.ch/unige:47538