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Title

Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons

Authors
Basker, M
Alwayn, I P
Harper, D
Abraham, S
Kruger Gray, H
DeAngelis, H
Awwad, M
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Published in Transplantation. 2001, vol. 72, no. 7, p. 1278-85
Abstract Attempts to achieve immunological tolerance to porcine tissues in nonhuman primates through establishment of mixed hematopoietic chimerism are hindered by the rapid clearance of mobilized porcine leukocytes, containing progenitor cells (pPBPCs), from the circulation. Eighteen hours after infusing 1-2 x 10(10) pPBPC/kg into baboons that had been depleted of circulating anti-alphaGal and complement, these cells are almost undetectable by flow cytometry. The aim of the present study was to identify mechanisms that contribute to rapid clearance of pPBPCs in the baboon. This was achieved by depleting, or blocking the Fc-receptors of, cells of the phagocytic reticuloendothelial system (RES) using medronate liposomes (MLs) or intravenous immunoglobulin (IVIg), respectively.
Keywords AnimalsBlood Cell CountDose-Response Relationship, DrugHematopoietic Stem Cell TransplantationHematopoietic Stem Cells/physiologyImmunoglobulins, Intravenous/pharmacologyLeukocyte CountLiposomesMacrophages/cytology/drug effectsMononuclear Phagocyte System/physiologyPapioPhagocytosis/physiologyReceptors, Fc/antagonists & inhibitorsSwineTime FactorsTransplantation Conditioning/methodsTransplantation, Heterologous
Identifiers
PMID: 11602856
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Research group Cultures cellulaires et transplantations (519)
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BASKER, M et al. Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons. In: Transplantation, 2001, vol. 72, n° 7, p. 1278-85. https://archive-ouverte.unige.ch/unige:47298

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Deposited on : 2015-02-26

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