Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

Berney, Thierry; Molano, R D; Cattan, P; Pileggi, A; Vizzardelli, C; Oliver, R; Ricordi, C; Inverardi, L

doi:10.1097/00007890-200101150-00020

Scientific article

English

Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

ContributorsBerney, Thierry; Molano, R D; Cattan, P; Pileggi, A; Vizzardelli, C; Oliver, R; Ricordi, C; Inverardi, L

Published inTransplantation, vol. 71, no. 1, p. 125-132

Publication date2001

Abstract

Primary nonfunction resulting in immediate graft loss is responsible for the failure of a large number of islet transplants. Evidence is accumulating to single out endotoxin contamination of the various reagents needed for islet isolation as a major cause of early graft loss.

Keywords

Animals
Apoptosis/drug effects
Cells, Cultured
Collagenases/pharmacology
Cytokines/biosynthesis
Endotoxins/pharmacology
Islets of Langerhans/chemistry/cytology/metabolism
Islets of Langerhans Transplantation/physiology
Male
Matrix Metalloproteinase 9/pharmacology
Mice
Mice, Inbred C57BL
Thermolysin/pharmacology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

La transplantation d'îlots de Langerhans (623)

Citation (ISO format)

BERNEY, Thierry et al. Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. In: Transplantation, 2001, vol. 71, n° 1, p. 125–132. doi: 10.1097/00007890-200101150-00020

Article (Published version)

Identifiers

PID : unige:47294
DOI : 10.1097/00007890-200101150-00020
PMID : 11211177

Journal ISSN0041-1337

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Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

Primary nonfunction resulting in immediate graft loss is responsible for the failure of a large number of islet transplants. Evidence is accumulating to single out endotoxin contamination of the various reagents needed for islet isolation as a major cause of early graft loss.

Technical informations