Scientific article
English

Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

Published in

Transplantation, vol. 71, no. 1, p. 125-132

Publication date

2001

Abstract

Primary nonfunction resulting in immediate graft loss is responsible for the failure of a large number of islet transplants. Evidence is accumulating to single out endotoxin contamination of the various reagents needed for islet isolation as a major cause of early graft loss.

Keywords

  • Animals
  • Apoptosis/drug effects
  • Cells, Cultured
  • Collagenases/pharmacology
  • Cytokines/biosynthesis
  • Endotoxins/pharmacology
  • Islets of Langerhans/chemistry/cytology/metabolism
  • Islets of Langerhans Transplantation/physiology
  • Male
  • Matrix Metalloproteinase 9/pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Thermolysin/pharmacology

Citation (ISO format)

BERNEY, Thierry et al. Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. In: Transplantation, 2001, vol. 71, n° 1, p. 125–132. doi: 10.1097/00007890-200101150-00020

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0041-1337
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Technical informations

Creation

25/02/2015 14:35:00

First validation

25/02/2015 14:35:00

Update

12/03/2026 10:41:09

Status update

12/03/2026 10:41:09

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12/03/2026 10:45:49
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