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Title

Patterns of engraftment in different strains of immunodeficient mice reconstituted with human peripheral blood lymphocytes

Authors
Molano, R D
Pileggi, A
Cattan, P
Li, H
Ricordi, C
Inverardi, L
Published in Transplantation. 2001, vol. 72, no. 1, p. 133-40
Abstract Models of immunodeficient mice reconstituted with a competent human immune system would represent an invaluable tool for the study of transplantation immunobiology allergy, autoimmunity, and infectious diseases. Severe combined immune deficiency (scid) mice can be successfully reconstituted with human peripheral blood lymphocytes (PBLs), but rates and levels of engraftment are poor. New strains of mice with diverse immunodeficiencies have been recently characterized or developed, which might prove to be advantageous for in vivo studies of human immune reactivity.
Keywords AnimalsAntibodies, Heterophile/analysisAntigens, CD3/metabolismBone Marrow/pathologyGraft vs Host Disease/pathologyHumansImmunoglobulins/metabolismKineticsLymphocyte TransfusionLymphocytes/physiologyMiceMice, Inbred C57BLMice, Inbred NODMice, SCIDPeritoneum/pathologyPhenotypeSevere Combined Immunodeficiency/immunology/therapySpleen/pathologySurvival AnalysisT-Lymphocytes/pathology/physiology
Identifiers
PMID: 11468548
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Research group La transplantation d'îlots de Langerhans (623)
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BERNEY, Thierry et al. Patterns of engraftment in different strains of immunodeficient mice reconstituted with human peripheral blood lymphocytes. In: Transplantation, 2001, vol. 72, n° 1, p. 133-40. https://archive-ouverte.unige.ch/unige:47293

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Deposited on : 2015-02-26

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