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Title

Formation of DNA-Copolymer Fibrils Through an Amyloid-Like Nucleation Polymerization Mechanism

Authors
Filippov, Sergey K.
Schlaad, Helmut
Published in Macromolecular Rapid Communications. 2015
Abstract Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.
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Other version: http://doi.wiley.com/10.1002/marc.201400728
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KEDRACKI, Dawid et al. Formation of DNA-Copolymer Fibrils Through an Amyloid-Like Nucleation Polymerization Mechanism. In: Macromolecular Rapid Communications, 2015. https://archive-ouverte.unige.ch/unige:47232

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Deposited on : 2015-02-24

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