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Title

The advantage of mucosal immunization for polysaccharide-specific memory responses in early life

Authors
Bjarnarson, Stefania P
Jakobsen, Håvard
Trannoy, Emanuelle
Jonsdottir, Ingileif
Published in European Journal of Immunology. 2005, vol. 35, no. 4, p. 1037-45
Abstract The aim of vaccination is to rapidly elicit protective immunity and generate memory for sustained protection. We studied the induction and persistence of polysaccharide (PS)-specific memory in neonatal and infant mice primed with pneumococcal conjugate (Pnc1-TT) by assessing the response to native pneumococcal PS (PPS-1), the kinetics of the PPS-1-specific IgG response to a second Pnc1-TT dose and affinity maturation. A subcutaneous (s.c.) Pnc1-TT booster induced a rapid increase in PPS-1-specific IgG, indicating efficient priming for memory by a single dose of Pnc1-TT already at 1 week of age. High levels were maintained for >12 weeks. However, a PPS-1 booster induced no response in neonatal or infant mice. The adjuvant LT-K63 significantly enhanced the IgG response and affinity to Pnc1-TT by both the s.c. and the intranasal (i.n.) route in all age groups. In neonatal and infant mice, PPS-1 and LT-K63 induced a booster response only when given i.n. following either s.c. or i.n. priming with Pnc1-TT and LT-K63. In contrast, PPS-1 with or without LT-K63 administered s.c. compromised the ongoing PPS-1-specific response elicited in neonatal mice by either s.c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life.
Keywords AnimalsBacterial Toxins/immunologyEnterotoxins/immunologyEscherichia coli Proteins/immunologyImmunity, Mucosal/immunologyImmunologic Memory/immunologyMicePolysaccharides, Bacterial/immunologyVaccines/immunology
Identifiers
PMID: 15756644
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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BJARNARSON, Stefania P et al. The advantage of mucosal immunization for polysaccharide-specific memory responses in early life. In: European Journal of Immunology, 2005, vol. 35, n° 4, p. 1037-45. https://archive-ouverte.unige.ch/unige:46885

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Deposited on : 2015-02-19

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