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European experience of docetaxel and cisplatin in advanced gastric cancer

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Published in Gastric Cancer. 2002, vol. 5 Suppl 1, p. 27-9
Abstract The combination of docetaxel with cisplatin in gastric cancer is a promising development. In a phase II study, 85-100 mg/m2 docetaxel plus 75 mg/m2 cisplatin was established as an active regimen in advanced gastric cancer (with an overall response rate of 56%) with a manageable safety profile. Up to 300 mg/m2 5-fluorouracil (5-FU) given by continuous infusion for 2 of 3 weeks can be added to this regimen without an increase in appreciable toxicity. The efficacy of docetaxel-based regimens remains to be established by a randomized phase III study. However, the results of such trials are eagerly awaited, as are data from studies of docetaxel-based combinations in the adjuvant and neoadjuvant settings.
Keywords AdultAgedAntineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic useCisplatin/administration & dosageDisease ProgressionDisease-Free SurvivalFemaleFluorouracil/administration & dosageHumansMaleMiddle AgedPaclitaxel/administration & dosage/analogs & derivativesStomach Neoplasms/drug therapy/pathologyTaxoids
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PMID: 12772884
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Research group Groupe Roth Arnaud (oncologie) (285)
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ROTH, Arnaud. European experience of docetaxel and cisplatin in advanced gastric cancer. In: Gastric Cancer, 2002, vol. 5 Suppl 1, p. 27-9. https://archive-ouverte.unige.ch/unige:46872

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Deposited on : 2015-02-19

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