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Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides

Teranishi, K
Gollackner, B
Knosalla, C
Correa, L
Down, J D
White-Scharf, M E
Sachs, D H
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Published in Transplantation. 2002, vol. 73, no. 1, p. 129-39
Abstract Anti-Galalpha 1-3Gal (Gal) antibodies (Ab) play a key role in the rejection of pig cells or organs transplanted into primates. A course of extracorporeal immunoadsorption (EIA) of anti-Gal Ab using an immunoaffinity column of a Gal type 6 oligosaccharide depletes Ab successfully, but Ab returns during the next few days. Although therapy with an anti-CD154 monoclonal antibody (mAb) prevents an induced Ab response to Gal or non-Gal epitopes, T cell-independent natural anti-Gal IgM and IgG return to baseline (pretransplant) levels. We have investigated the capacity of continuous i.v. infusion of bovine serum albumin conjugated to Gal type 6 oligosaccharide (BSA-Gal) to deplete or maintain depletion of circulating anti-Gal Ab.
Keywords AnimalsAntibodies, Monoclonal/administration & dosage/therapeutic useAntibody FormationCD40 Ligand/immunologyCarbohydrate SequenceDisaccharides/immunologyGalactose/administration & dosage/therapeutic useGraft Rejection/immunologyGraft Survival/drug effects/immunologyHematopoietic Cell Growth Factors/therapeutic useHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationImmunosorbent TechniquesImmunosuppression/methodsInfusions, IntravenousMolecular Sequence DataOligosaccharides/administration & dosage/chemistry/therapeutic usePapioPrimatesSerum Albumin, Bovine/administration & dosage/therapeutic useSwineSwine, MiniatureTime FactorsTransplantation, Heterologous/immunologyWhole-Body Irradiation
PMID: 11792992
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Research group Cultures cellulaires et transplantations (519)
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TERANISHI, K et al. Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides. In: Transplantation, 2002, vol. 73, n° 1, p. 129-39. doi: 10.1097/00007890-200201150-00024 https://archive-ouverte.unige.ch/unige:46863

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Deposited on : 2015-02-19

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