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Scientific article
English

Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways

Published inPlacenta, vol. 36, no. 4, p. 419-426
Publication date2015
Abstract

The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophoblasts and exerts pleiotropic effects on the immune system, including the promotion of inflammation and the activation of T cell responses.

Citation (ISO format)
BARRIENTOS, G et al. Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways. In: Placenta, 2015, vol. 36, n° 4, p. 419–426. doi: 10.1016/j.placenta.2015.01.006
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Identifiers
ISSN of the journal0143-4004
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Technical informations

Creation02/17/2015 4:39:00 PM
First validation02/17/2015 4:39:00 PM
Update time03/14/2023 10:50:55 PM
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