Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways

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Title		Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways
Authors		Barrientos, G Toro, A Moschansky, P Cohen, Marie-Benoîte Garcia, M G Rose, M Maskin, B Sánchez-Margalet, V Blois, S M Varone, C L show all authors [1 - 10]
Published in		Placenta. 2015, vol. 36, no. 4, p. 419-26
Abstract		The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophoblasts and exerts pleiotropic effects on the immune system, including the promotion of inflammation and the activation of T cell responses.
Identifiers		DOI: 10.1016/j.placenta.2015.01.006 PMID: 25649687
Full text		Article (Published version) (1 MB) - Limited access to UNIGE Article (Published version) (1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de gynécologie et d'obstétrique
Research group		Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
Citation (ISO format)		BARRIENTOS, G et al. Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways. In: Placenta, 2015, vol. 36, n° 4, p. 419-26. https://archive-ouverte.unige.ch/unige:46768