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Title

Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways

Authors
Barrientos, G
Toro, A
Moschansky, P
Garcia, M G
Rose, M
Maskin, B
Sánchez-Margalet, V
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Published in Placenta. 2015, vol. 36, no. 4, p. 419-26
Abstract The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophoblasts and exerts pleiotropic effects on the immune system, including the promotion of inflammation and the activation of T cell responses.
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PMID: 25649687
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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BARRIENTOS, G et al. Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways. In: Placenta, 2015, vol. 36, n° 4, p. 419-26. https://archive-ouverte.unige.ch/unige:46768

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Deposited on : 2015-02-18

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