Article (Published version) (356 Kb) - Limited access to UNIGE
Can successful vaccines teach us how to induce efficient protective immune responses?
|Published in||Nature Medicine. 2005, vol. 11, no. 4 Suppl, p. S54-62|
|Abstract||Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection. In fact, successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases.|
|Keywords||Aged — Antibodies/blood — Antibody Affinity — Antigenic Variation — Antigens/immunology — Humans — Immunity, Cellular — Immunologic Memory — Infant — Vaccines/immunology|
|Research group||Centre de Vaccinologie et d'Immunologie néonatale (177)|
|LAMBERT, Paul Henri, LIU, Margaret, SIEGRIST, Claire-Anne. Can successful vaccines teach us how to induce efficient protective immune responses?. In: Nature Medicine, 2005, vol. 11, n° 4 Suppl, p. S54-62. https://archive-ouverte.unige.ch/unige:46638|