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Title

Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease

Authors
Rademaker, Karin
Zimine, Slava
Lieftink, Arno F
Groenendaal, Floris
de Vries, Linda S
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Published in Pediatrics. 2005, vol. 116, no. 1, p. 1-7
Abstract There is much concern about potential neurodevelopmental impairment after neonatal corticosteroid treatment for chronic lung disease. Dexamethasone is the corticosteroid most often used in this clinical setting, and it has been shown to impair cortical growth among preterm infants. This study evaluated long-term effects of prematurity itself and of neonatal hydrocortisone treatment on structural and functional brain development using three-dimensional MRI with advanced image-processing and neurocognitive assessments.
Keywords Anti-Inflammatory Agents/adverse effects/therapeutic useBrain/drug effects/pathologyChildChronic DiseaseFollow-Up StudiesHumansHydrocortisone/adverse effects/therapeutic useInfant, NewbornInfant, PrematureInfant, Premature, Diseases/drug therapyIntelligence/drug effectsLung Diseases/drug therapyMagnetic Resonance ImagingWechsler Scales
Identifiers
PMID: 15995023
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Structures
Research groups L'imagerie cérébrale (184)
Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539)
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(ISO format)
LODYGENSKY, Gregory Anton et al. Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease. In: Pediatrics, 2005, vol. 116, n° 1, p. 1-7. https://archive-ouverte.unige.ch/unige:46636

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Deposited on : 2015-02-12

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