en
Scientific article
Review
French

Perspectives dans le traitement du diabète par transplantation de pancréas ou greffe d'îlots de Langerhans

Published inDiabetes & metabolism, vol. 28, no. 4 Pt 2, p. 2S27-2S32
Publication date2002
Abstract

Replacement of beta-cell function by transplantation of endocrine tissue is an alternative treatment for patients with complicated type 1 diabetes. Pancreas transplantation is presently the only treatment allowing to normalise glycemia without increasing the risk of hypoglycemia and to stop exogenous insulin-therapy. In spite of postoperative morbidity and mortality, pancreas transplantation improves quality of life, reduces cardiovascular risk factors and prolongs the life expectancy of diabetic patients with end-stage kidney failure. Islet transplantation is still an experimental procedure. However, the results obtained recently are a proof of principle that a cellular transplant can induce normoglycemia and insulin-independence in diabetic patients. In this review, the results and perspectives of pancreas and islet transplantation are discussed.

Keywords
  • Diabetes Mellitus, Type 1/surgery
  • Islets of Langerhans Transplantation
  • Pancreas Transplantation
Citation (ISO format)
OBERHOLZER, José, MOREL, Philippe. Perspectives dans le traitement du diabète par transplantation de pancréas ou greffe d’îlots de Langerhans. In: Diabetes & metabolism, 2002, vol. 28, n° 4 Pt 2, p. 2S27–2S32.
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1262-3636
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