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Title

Perspectives dans le traitement du diabète par transplantation de pancréas ou greffe d'îlots de Langerhans

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Published in Diabetes & Metabolism. 2002, vol. 28, no. 4 Pt 2, p. 2S27-2S32
Abstract Replacement of beta-cell function by transplantation of endocrine tissue is an alternative treatment for patients with complicated type 1 diabetes. Pancreas transplantation is presently the only treatment allowing to normalise glycemia without increasing the risk of hypoglycemia and to stop exogenous insulin-therapy. In spite of postoperative morbidity and mortality, pancreas transplantation improves quality of life, reduces cardiovascular risk factors and prolongs the life expectancy of diabetic patients with end-stage kidney failure. Islet transplantation is still an experimental procedure. However, the results obtained recently are a proof of principle that a cellular transplant can induce normoglycemia and insulin-independence in diabetic patients. In this review, the results and perspectives of pancreas and islet transplantation are discussed.
Keywords Diabetes Mellitus, Type 1/surgeryIslets of Langerhans TransplantationPancreas Transplantation
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PMID: 12442061
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Article (Published version) (1.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Chirurgie viscérale (104)
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OBERHOLZER, José, MOREL, Philippe. Perspectives dans le traitement du diabète par transplantation de pancréas ou greffe d'îlots de Langerhans. In: Diabetes & Metabolism, 2002, vol. 28, n° 4 Pt 2, p. 2S27-2S32. https://archive-ouverte.unige.ch/unige:46459

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Deposited on : 2015-02-05

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