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Management of postpneumonectomy Aspergillus empyema extending into the thoracic wall: a plea for radical surgery and caution when using liposomal amphotericin B.
|Published in||Interactive Cardiovascular and Thoracic Surgery. 2003, vol. 2, no. 4, p. 682-684|
|Abstract||Semi-invasive aspergillosis is a rare disease leading to severe complications even in fully immunocompetent patients. The therapeutic role of systemic and intrapleural antifungal agents remains not well known. We report herein the case of a 54-year-old woman who developed Aspergillus empyema invading the thoracic wall and subcutaneous tissues after completion pneumonectomy for aspergilloma. She initially was treated conservatively with systemic and intrapleural amphotericin B without any success and developed a severe anaphylactic reaction to intravenous liposomal amphotericin B (Ambisome). She then underwent an open-window thoracotomy with intrathoracic transposition of a latissimus dorsi muscle flap and was started on itraconazole therapy. The thoracostomy was closed after 6 months and the patient is doing well without any signs of recurrent infection after 3 years.|
|Research group||Dysfonctions cardio-pulmonaires et cérébrales (278)|
|LAMPO, N et al. Management of postpneumonectomy Aspergillus empyema extending into the thoracic wall: a plea for radical surgery and caution when using liposomal amphotericin B. In: Interactive Cardiovascular and Thoracic Surgery, 2003, vol. 2, n° 4, p. 682-684. https://archive-ouverte.unige.ch/unige:46203|