UNIGE document Scientific Article - Review
previous document  unige:46010  next document
add to browser collection
Title

The importance of early treatment for the prognosis of rheumatoid arthritis

Authors
Kyburz, Diego
Published in Swiss Medical Weekly. 2013, vol. 143, p. w13865
Abstract Chronic synovial inflammation in rheumatoid arthritis (RA) leads to progressive damage to articular cartilage and bone, ultimately resulting in disability. Therefore, control of the articular inflammation is of great importance to prevent joint damage. A variety of disease-modifying antirheumatic drugs (DMARDs) are available for RA patients. Conventional synthetic DMARDs, and in particular biological DMARDs, have been shown to effectively inhibit joint destruction in RA. Longitudinal assessments of radiographic changes in patients with RA in clinical trials and in large patient registries have clearly shown that delays in the initiation of DMARD therapy results in significantly increased progression of joint damage. Patients started early on DMARDs had significantly lower radiographic damage progression than patients initiating DMARD treatment later. These effects were maintained for several years, suggesting that early in the development of RA a therapeutic window of opportunity exists in which DMARD therapy decisively influences the long-term prognosis. Therefore, to improve the clinical outcome of RA, our efforts should be directed towards diagnosing RA earlier and introducing DMARD therapy immediately after the diagnosis has been made.
Keywords Antirheumatic Agents/therapeutic useArthritis, Rheumatoid/diagnosis/drug therapyDisease ProgressionEarly DiagnosisEarly Medical InterventionHumansPrognosisTime-to-TreatmentTreatment Outcome
Identifiers
PMID: 24089023
Full text
Article (Published version) (473 Kb) - public document Free access
Structures
Research group Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format)
KYBURZ, Diego, FINCKH, Axel. The importance of early treatment for the prognosis of rheumatoid arthritis. In: Swiss Medical Weekly, 2013, vol. 143, p. w13865. https://archive-ouverte.unige.ch/unige:46010

191 hits

50 downloads

Update

Deposited on : 2015-01-29

Export document
Format :
Citation style :