UNIGE document Scientific Article
previous document  unige:4601  next document
add to browser collection
Title

Expression profiles of urbilaterian genes uniquely shared between honey bee and vertebrates

Authors
Matsui, Toshiaki
Yamamoto, Toshiyuki
Kadowaki, Tatsuhiko
Published in BMC Genomics. 2009, vol. 10, 17
Abstract BACKGROUND: Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the present functions of these ancient genes have not been addressed extensively. To understand the functions and evolutionary mechanisms of such ancient Urbilaterian genes, we carried out comprehensive expression profile analysis of genes shared between vertebrates and honey bees but not with the other sequenced ecdysozoan genomes (honey bee-vertebrate specific, HVS genes) as a model. RESULTS: We identified 30 honey bee and 55 mouse HVS genes. Many HVS genes exhibited tissue-selective expression patterns; intriguingly, the expression of 60% of honey bee HVS genes was found to be brain enriched, and 24% of mouse HVS genes were highly expressed in either or both the brain and testis. Moreover, a minimum of 38% of mouse HVS genes demonstrated neuron-enriched expression patterns, and 62% of them exhibited expression in selective brain areas, particularly the forebrain and cerebellum. Furthermore, gene ontology (GO) analysis of HVS genes predicted that 35% of genes are associated with DNA transcription and RNA processing. CONCLUSION: These results suggest that HVS genes include genes that are biased towards expression in the brain and gonads. They also demonstrate that at least some of Urbilaterian genes retained in the specific animal lineage may be selectively maintained to support the species-specific phenotypes.
Keywords AnimalsBees/geneticsBrain/metabolismEvolutionGene Expression ProfilingGenes, InsectGenomicsMice/geneticsRNA/geneticsSpecies Specificity
Identifiers
PMID: 19138430
Full text
Structures
Research group Génomique Evolutionnaire Computationnelle (830)
Citation
(ISO format)
MATSUI, Toshiaki et al. Expression profiles of urbilaterian genes uniquely shared between honey bee and vertebrates. In: BMC Genomics, 2009, vol. 10, p. 17. doi: 10.1186/1471-2164-10-17 https://archive-ouverte.unige.ch/unige:4601

489 hits

328 downloads

Update

Deposited on : 2009-12-03

Export document
Format :
Citation style :