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Title

In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Authors
Nogueira, Leonor
Cornillet, Martin
Singwe-Ngandeu, Madeleine
Serre, Guy
Published in Clinical Immunology. 2014, vol. 152, no. 1-2, p. 58-64
Abstract Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificities have not yet been studied. Here, we show that in Cameroonian patients, anti-citrullinated fibrinogen autoantibodies (AhFibA) are sensitive (73%) diagnostic markers for RA. We also determine that autoantibodies directed to α36-50Cit38,42 or β60-74Cit60,72,74 peptides which bear the immunodominant epitopes of citrullinated fibrin, are present in similar proportions in Black Africans and Caucasians with 25/56 (45%) and 41/56 (73%) positive RA-sera in Cameroonians, respectively. They also account for almost all the AhFibA reactivities since 38/41 (93%) AhFibA-positive sera contain anti-α36-50Cit38,42 and/or anti-β60-74Cit60,72,74 autoantibodies. Finally, HLA-DRB1 SE alleles were associated with higher titres of AhFibA and anti-β60-74Cit60,72,74 autoantibodies. In the genetic and environmental backgrounds of Black Africans, AhFibA are a hallmark of RA like in Caucasians, moreover they recognize the same fibrin epitopes.
Keywords AfricaAfrican Continental Ancestry GroupAmino Acid SequenceArthritis, Rheumatoid/diagnosis/genetics/immunologyAutoantibodies/immunologyBiological Markers/analysisCitrulline/immunologyEpitopes/genetics/immunologyEuropean Continental Ancestry GroupFibrinogen/immunologyHLA-DRB1 ChainsHumansPeptides/genetics/immunology
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PMID: 24589748
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Research group Mécanisme de l'inflammation articulaire (44)
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NOGUEIRA, Leonor et al. In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians. In: Clinical Immunology, 2014, vol. 152, n° 1-2, p. 58-64. https://archive-ouverte.unige.ch/unige:45957

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Deposited on : 2015-01-28

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