en
Scientific article
English

Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout

Published inArthritis & rheumatology, vol. 66, no. 5, p. 1327-1339
Publication date2014
Abstract

Monosodium urate monohydrate (MSU) crystal-induced interleukin-1β (IL-1β) secretion is a critical factor in the pathogenesis of gout. However, without costimulation by a proIL-1β-inducing factor, MSU crystals alone are insufficient to induce IL-1β secretion. The responsible costimulatory factors that act as a priming endogenous signal in vivo are not yet known. We undertook this study to analyze the costimulatory properties of myeloid-related protein 8 (MRP-8) and MRP-14 (endogenous Toll-like receptor 4 [TLR-4] agonists) in MSU crystal-induced IL-1β secretion and their relevance in gout.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Calgranulin A/metabolism
  • Calgranulin B/metabolism
  • Cells, Cultured
  • Crystallization
  • Disease Models, Animal
  • Female
  • Gout/metabolism
  • Humans
  • Inflammation/metabolism
  • Interleukin-1beta/metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Phagocytes/metabolism
  • Toll-Like Receptor 4/deficiency/genetics/metabolism
  • Uric Acid/metabolism
Citation (ISO format)
HOLZINGER, Dirk et al. Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. In: Arthritis & rheumatology, 2014, vol. 66, n° 5, p. 1327–1339. doi: 10.1002/art.38369
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Article (Published version)
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Identifiers
ISSN of the journal2326-5191
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