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Title

Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout

Authors
Holzinger, Dirk
Nippe, Nadine
Vogl, Thomas
Marketon, Kristina
Mysore, Vijayashree
Weinhage, Toni
Dalbeth, Nicola
Pool, Bregina
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Published in Arthritis and Rheumatology. 2014, vol. 66, no. 5, p. 1327-39
Abstract Monosodium urate monohydrate (MSU) crystal-induced interleukin-1β (IL-1β) secretion is a critical factor in the pathogenesis of gout. However, without costimulation by a proIL-1β-inducing factor, MSU crystals alone are insufficient to induce IL-1β secretion. The responsible costimulatory factors that act as a priming endogenous signal in vivo are not yet known. We undertook this study to analyze the costimulatory properties of myeloid-related protein 8 (MRP-8) and MRP-14 (endogenous Toll-like receptor 4 [TLR-4] agonists) in MSU crystal-induced IL-1β secretion and their relevance in gout.
Keywords AdultAgedAged, 80 and overAnimalsCalgranulin A/metabolismCalgranulin B/metabolismCells, CulturedCrystallizationDisease Models, AnimalFemaleGout/metabolismHumansInflammation/metabolismInterleukin-1beta/metabolismMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedPhagocytes/metabolismToll-Like Receptor 4/deficiency/genetics/metabolismUric Acid/metabolism
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PMID: 24470119
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Research group Mécanisme de l'inflammation articulaire (44)
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HOLZINGER, Dirk et al. Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. In: Arthritis and rheumatology, 2014, vol. 66, n° 5, p. 1327-39. https://archive-ouverte.unige.ch/unige:45956

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Deposited on : 2015-01-28

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