UNIGE document Scientific Article
previous document  unige:45823  next document
add to browser collection
Title

Severe Neutrophil-Dominated Inflammation and Enhanced Myelopoiesis in IL-33-Overexpressing CMV/IL33 Mice

Authors
Published in Journal of Immunology. 2015, vol. 194, no. 2, p. 750-60
Abstract IL-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous studies emphasized a role for IL-33 in shaping innate and adaptive immune responses. IL-33 was also reported to modulate myelopoiesis and myeloid cell activity. In this article, we describe IL-33-overexpressing CMV/IL33 and LysM/IL33 mice, which display an inflammatory phenotype associated with growth retardation and paw swelling. The phenotype of CMV/IL33 mice is dependent on activation of the ST2 receptor and is characterized by extensive neutrophil infiltration into different organs, including the paws. Local or systemic levels of proinflammatory mediators such as IL-1β, Cxcl-1, G-CSF, and IL-6 are increased. CMV/IL-33 mice also suffer from anemia, thrombocytosis, and a marked dysregulation of myelopoiesis, leading to an important increase in myeloid cell production or accumulation in bone marrow (BM), spleen, and peripheral blood. Consistently, recombinant IL-33 induced proliferation of myeloid lineage cells in BM-derived granulocyte cultures, whereas IL-33 knockout mice exhibited minor deficiencies in spleen and BM myeloid cell populations. Our observations reveal a neutrophil-dominated inflammatory phenotype in IL-33-overexpressing CMV/IL33 and LysM/IL33 mice, and highlight important regulatory effects of IL-33 on myelopoiesis in vitro and in vivo, where excessive IL-33 signaling can translate into the occurrence of a myeloproliferative disorder.
Identifiers
PMID: 25505285
Full text
Article (Published version) (2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format)
TALABOT FRISCHKNECHT-AYER, Dominique et al. Severe Neutrophil-Dominated Inflammation and Enhanced Myelopoiesis in IL-33-Overexpressing CMV/IL33 Mice. In: Journal of Immunology, 2015, vol. 194, n° 2, p. 750-60. https://archive-ouverte.unige.ch/unige:45823

209 hits

1 download

Update

Deposited on : 2015-01-23

Export document
Format :
Citation style :