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ABO-incompatible organ and bone marrow transplantation: current status

Wu, Anette
Cooper, David K C
Published in Transplant international. 2003, vol. 16, no. 5, p. 291-9
Abstract Despite the presence of preformed antibodies against AB oligosaccharide epitopes on the donor vascular endothelium, approximately one-third of ABO-incompatible organ allografts are not rejected by a humoral mechanism. With the growing immune-manipulation of the recipient, survival rates can be raised considerably, although they remain significantly inferior to those of ABO-compatible transplantation. Data from the Collaborative Transplant Study indicate a 1-year graft survival rate of approximately 50-60% following cadaveric ABO-incompatible kidney, liver or heart transplantation, compared with 70-80% for an ABO-compatible organ. The results for infants and young children, however, are very much better than those of adults, particularly for liver and heart transplantations, and the data suggest that B-cell tolerance can develop in the infant age group. We here review clinical and experimental experience with ABO-incompatible organ and bone marrow allotransplantation and address the mechanisms by which organs or cells survive in the presence of natural anti-carbohydrate antibodies.
Keywords ABO Blood-Group System/immunologyBone Marrow Transplantation/immunologyHistocompatibility TestingHumansImmune ToleranceTransplants
PMID: 12719804
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Research group Cultures cellulaires et transplantations (519)
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WU, Anette, BUEHLER, Leo Hans, COOPER, David K C. ABO-incompatible organ and bone marrow transplantation: current status. In: Transplant international, 2003, vol. 16, n° 5, p. 291-9. doi: 10.1007/s00147-003-0592-4 https://archive-ouverte.unige.ch/unige:45735

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Deposited on : 2015-01-22

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