Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade

Buehler, Leo Hans; Awwad, M; Treter, S; Chang, Q; Basker, M; Alwayn, I P J; Teranishi, K; Ericsson, T; Moran, K; Harper, D; Kurilla-Mahon, B; Huang, C A; Sackstein, R; Sykes, M; White-Scharf, M E; Sachs, D H; Down, J D; Cooper, D K

doi:10.1097/00007890-200201150-00001

Scientific article

English

Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade

ContributorsBuehler, Leo Hans; Awwad, M; Treter, S; Chang, Q; Basker, M; Alwayn, I P J; Teranishi, K; Ericsson, T; Moran, K; Harper, D; Kurilla-Mahon, B; Huang, C A; Sackstein, R; Sykes, M; White-Scharf, M E; Sachs, D H; Down, J D; Cooper, D K

Published inTransplantation, vol. 73, no. 1, p. 12-22

Publication date2002

Abstract

In an attempt to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, we have infused high-dose porcine peripheral blood progenitor cells (PBPC) into baboons pretreated with a nonmyeloablative regimen and anti-CD154 monoclonal antibody (mAb).

Keywords

Animals
CD40 Ligand/immunology
Carbohydrate Sequence
Colony-Forming Units Assay
Haplotypes/genetics
Hematopoietic Cell Growth Factors/therapeutic use
Hematopoietic Stem Cell Mobilization/methods
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Interleukin-3/blood
Leukapheresis
Molecular Sequence Data
Papio
Swine
Swine, Miniature
Transplantation Chimera
Transplantation, Heterologous/immunology
Trisaccharides/blood/isolation & purification

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cultures cellulaires et transplantations (519)

Citation (ISO format)

BUEHLER, Leo Hans et al. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. In: Transplantation, 2002, vol. 73, n° 1, p. 12–22. doi: 10.1097/00007890-200201150-00001

Article (Published version)

Identifiers

PID : unige:45715
DOI : 10.1097/00007890-200201150-00001
PMID : 11792972

Journal ISSN0041-1337

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Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade

In an attempt to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, we have infused high-dose porcine peripheral blood progenitor cells (PBPC) into baboons pretreated with a nonmyeloablative regimen and anti-CD154 monoclonal antibody (mAb).

Technical informations