Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease

Buehler, Leo Hans; Spitzer, Thomas R; Sykes, Megan; Sachs, David H; Delmonico, Francis L; Tolkoff-Rubin, Nina; Saidman, Susan L; Sackstein, Robert; McAfee, Steven; Dey, Bimalangshu; Colby, Christine; Cosimi, A Benedict

doi:10.1097/01.TP.0000034627.37442.A4

Scientific article

English

Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease

ContributorsBuehler, Leo Hans; Spitzer, Thomas R; Sykes, Megan; Sachs, David H; Delmonico, Francis L; Tolkoff-Rubin, Nina; Saidman, Susan L; Sackstein, Robert; McAfee, Steven; Dey, Bimalangshu; Colby, Christine; Cosimi, A Benedict

Published inTransplantation, vol. 74, no. 10, p. 1405-1409

Publication date2002

Abstract

Two patients with end-stage renal disease secondary to multiple myelomas were treated with combined kidney and bone marrow transplantation in an effort to achieve donor-specific allotolerance through the induction of mixed lymphohematopoietic chimerism.

Keywords

Bone Marrow Transplantation
Female
Graft vs Host Disease/etiology
Humans
Immune Tolerance
Kidney Failure, Chronic/therapy
Kidney Transplantation
Lymphopoiesis/immunology
Middle Aged
Multiple Myeloma/complications/therapy
Transplantation Chimera/immunology
Transplantation, Homologous

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cultures cellulaires et transplantations (519)

Citation (ISO format)

BUEHLER, Leo Hans et al. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. In: Transplantation, 2002, vol. 74, n° 10, p. 1405–1409. doi: 10.1097/01.TP.0000034627.37442.A4

Article (Published version)

Identifiers

PID : unige:45712
DOI : 10.1097/01.TP.0000034627.37442.A4
PMID : 12451240

Journal ISSN0041-1337

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Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease

Two patients with end-stage renal disease secondary to multiple myelomas were treated with combined kidney and bone marrow transplantation in an effort to achieve donor-specific allotolerance through the induction of mixed lymphohematopoietic chimerism.

Technical informations