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Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes

Cattan, Pierre
Conti, Filomena
Calmus, Yvon
Homberg, J C
Houssin, Didier
Soubrane, Olivier
Published in Transplant international. 2002, vol. 15, no. 1, p. 34-8
Abstract The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.
Keywords AdolescentAdultChildFemaleHepatitis, Autoimmune/classification/surgeryHumansLiver Transplantation/methods/mortality/statistics & numerical dataPostoperative Complications/epidemiology/mortality/surgeryRecurrenceReoperationSurvival AnalysisTreatment Outcome
PMID: 11875611
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Research group La transplantation d'îlots de Langerhans (623)
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CATTAN, Pierre et al. Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes. In: Transplant international, 2002, vol. 15, n° 1, p. 34-8. doi: 10.1007/s00147-001-0376-7 https://archive-ouverte.unige.ch/unige:45710

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Deposited on : 2015-01-22

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