en
Scientific article
English

Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes

Published inTransplant international, vol. 15, no. 1, p. 34-38
Publication date2002
Abstract

The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.

Keywords
  • Adolescent
  • Adult
  • Child
  • Female
  • Hepatitis, Autoimmune/classification/surgery
  • Humans
  • Liver Transplantation/methods/mortality/statistics & numerical data
  • Postoperative Complications/epidemiology/mortality/surgery
  • Recurrence
  • Reoperation
  • Survival Analysis
  • Treatment Outcome
Citation (ISO format)
CATTAN, Pierre et al. Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes. In: Transplant international, 2002, vol. 15, n° 1, p. 34–38. doi: 10.1007/s00147-001-0376-7
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0934-0874
484views
0downloads

Technical informations

Creation01/21/2015 11:31:00 AM
First validation01/21/2015 11:31:00 AM
Update time03/14/2023 10:44:19 PM
Status update03/14/2023 10:44:19 PM
Last indexation01/16/2024 4:23:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack