UNIGE document Scientific Article
previous document  unige:45710  next document
add to browser collection
Title

Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes
Authors
Cattan, Pierre
Berney, Thierry
Conti, Filomena
Calmus, Yvon
Homberg, J C
Houssin, Didier
Soubrane, Olivier
Published in Transplant International. 2002, vol. 15, no. 1, p. 34-8
Abstract The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.
Keywords Adolescent — Adult — Child — Female — Hepatitis, Autoimmune/classification/surgery — Humans — Liver Transplantation/methods/mortality/statistics & numerical data — Postoperative Complications/epidemiology/mortality/surgery — Recurrence — Reoperation — Survival Analysis — Treatment Outcome
Identifiers
PMID: 11875611
Full text
Article (Published version) (452 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group La transplantation d'îlots de Langerhans (623)
Citation
(ISO format) 		CATTAN, Pierre et al. Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes. In: Transplant International, 2002, vol. 15, n° 1, p. 34-8. https://archive-ouverte.unige.ch/unige:45710

186 hits

0 download

Contact an author

Update request

Update

Deposited on : 2015-01-22

Export document
Format :
Citation style :