Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes

Cattan, Pierre; Berney, Thierry; Conti, Filomena; Calmus, Yvon; Homberg, J C; Houssin, Didier; Soubrane, Olivier

doi:10.1007/s00147-001-0376-7

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Title		Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes
Authors		Cattan, Pierre Berney, Thierry Conti, Filomena Calmus, Yvon Homberg, J C Houssin, Didier Soubrane, Olivier
Published in		Transplant international. 2002, vol. 15, no. 1, p. 34-8
Abstract		The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.
Keywords		Adolescent — Adult — Child — Female — Hepatitis, Autoimmune/classification/surgery — Humans — Liver Transplantation/methods/mortality/statistics & numerical data — Postoperative Complications/epidemiology/mortality/surgery — Recurrence — Reoperation — Survival Analysis — Treatment Outcome
Identifiers		DOI: 10.1007/s00147-001-0376-7 PMID: 11875611
Full text		Article (Published version) (452 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		La transplantation d'îlots de Langerhans (623)
Citation (ISO format)		CATTAN, Pierre et al. Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes. In: Transplant international, 2002, vol. 15, n° 1, p. 34-8. doi: 10.1007/s00147-001-0376-7 https://archive-ouverte.unige.ch/unige:45710