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Title

A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

Authors
Derfuss, Tobias
Guebelin, Claudia
Rasenack, Maria
Pasquier, Renaud Du
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Published in Multiple Sclerosis Journal. 2014, vol. n/a
Abstract GNbAC1 is an immunoglobulin (IgG4) humanised monoclonal antibody against multiple sclerosis-associated retrovirus (MSRV)-Env, a protein of endogenous retroviral origin, expressed in multiple sclerosis (MS) lesions, which is pro-inflammatory and inhibits oligodendrocyte precursor cell differentiation.
Identifiers
PMID: 25392325
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Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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DERFUSS, Tobias et al. A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients. In: Multiple Sclerosis Journal, 2014, vol. n/a. https://archive-ouverte.unige.ch/unige:45606

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Deposited on : 2015-01-20

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