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Title

Fulminant Lewy body disease

Authors
Momjian-Mayor, Isabelle
Published in Movement Disorders. 2006, vol. 21, no. 10, p. 1748-51
Abstract The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.
Keywords 14-3-3 Proteins/analysisAgedBrain/pathologyCreutzfeldt-Jakob Syndrome/diagnosis/pathologyDiagnosis, DifferentialDisease ProgressionFatal OutcomeHumansLewy Bodies/pathologyLewy Body Disease/diagnosis/pathologyMaleNeurologic ExaminationNeuropsychological TestsParkinson Disease/diagnosis/pathology
Identifiers
PMID: 16830307
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Article (Published version) (152 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Pierre Burkhard (neurologie) (154)
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(ISO format)
MOMJIAN-MAYOR, Isabelle et al. Fulminant Lewy body disease. In: Movement Disorders, 2006, vol. 21, n° 10, p. 1748-51. https://archive-ouverte.unige.ch/unige:45500

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Deposited on : 2015-01-19

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