en
Scientific article
Case report
English

Fulminant Lewy body disease

Published inMovement disorders, vol. 21, no. 10, p. 1748-1751
Publication date2006
Abstract

The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.

Keywords
  • 14-3-3 Proteins/analysis
  • Aged
  • Brain/pathology
  • Creutzfeldt-Jakob Syndrome/diagnosis/pathology
  • Diagnosis, Differential
  • Disease Progression
  • Fatal Outcome
  • Humans
  • Lewy Bodies/pathology
  • Lewy Body Disease/diagnosis/pathology
  • Male
  • Neurologic Examination
  • Neuropsychological Tests
  • Parkinson Disease/diagnosis/pathology
Citation (ISO format)
MOMJIAN-MAYOR, Isabelle et al. Fulminant Lewy body disease. In: Movement disorders, 2006, vol. 21, n° 10, p. 1748–1751. doi: 10.1002/mds.21034
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0885-3185
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