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Scientific Article - Case report
unige:45500 
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Fulminant Lewy body disease |
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| Authors | ||
| Published in | Movement Disorders. 2006, vol. 21, no. 10, p. 1748-51 | |
| Abstract | The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity. | |
| Keywords | 14-3-3 Proteins/analysis — Aged — Brain/pathology — Creutzfeldt-Jakob Syndrome/diagnosis/pathology — Diagnosis, Differential — Disease Progression — Fatal Outcome — Humans — Lewy Bodies/pathology — Lewy Body Disease/diagnosis/pathology — Male — Neurologic Examination — Neuropsychological Tests — Parkinson Disease/diagnosis/pathology | |
| Identifiers | DOI: 10.1002/mds.21034 PMID: 16830307 | |
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| Structures | ||
| Research group | Groupe Pierre Burkhard (neurologie) (154) | |
| Citation (ISO format) | MOMJIAN-MAYOR, Isabelle et al. Fulminant Lewy body disease. In: Movement Disorders, 2006, vol. 21, n° 10, p. 1748-51. doi: 10.1002/mds.21034 https://archive-ouverte.unige.ch/unige:45500 |
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