Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons

Teranishi, Katsuhito; Alwayn, Ian P J; Buehler, Leo Hans; Gollackner, Bernd; Knosalla, Christoph; Huck, Jennifer; Duthaler, Rudolf; Katopodis, Andreas; Sachs, David H; Schuurman, Henk-Jan; Awwad, Michel; Cooper, David K C

doi:10.1034/j.1399-3089.2003.02078.x

Scientific article

English

Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons

ContributorsTeranishi, Katsuhito; Alwayn, Ian P J; Buehler, Leo Hans; Gollackner, Bernd; Knosalla, Christoph; Huck, Jennifer; Duthaler, Rudolf; Katopodis, Andreas; Sachs, David H; Schuurman, Henk-Jan; Awwad, Michel; Cooper, David K C

Published inXenotransplantation, vol. 10, no. 4, p. 357-367

Publication date2003

Abstract

Natural anti-Gal antibodies (NAb) to Gal epitopes play a key role in the rejection of pig cells or organs transplanted into primates. We have investigated the effect on NAb return after extracorporeal immunoadsorption (EIA) of the continuous intravenous (i.v.) infusion of (i) bovine serum albumin conjugated to Gal type 6 oligosaccharides (BSA-Gal) or (ii) a poly l-lysine backbone conjugated to Gal type 2 or 6 oligosaccharides (PLL-Gal).

Keywords

Animals
Antibodies, Heterophile/blood/immunology
Galactose/immunology
Glycoconjugates/immunology/pharmacology
Graft Rejection/immunology/mortality/pathology
Hematopoiesis/immunology
Hematopoietic Stem Cell Transplantation
Immune Tolerance/immunology
Intestine, Small/pathology
Lung/pathology
Myocardium/pathology
Papio
Serum Albumin, Bovine/pharmacology
Survival Rate
Swine, Miniature
Transplantation Chimera
Transplantation, Heterologous/immunology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cultures cellulaires et transplantations (519)

Citation (ISO format)

TERANISHI, Katsuhito et al. Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons. In: Xenotransplantation, 2003, vol. 10, n° 4, p. 357–367. doi: 10.1034/j.1399-3089.2003.02078.x

Article (Published version)

Identifiers

PID : unige:45479
DOI : 10.1034/j.1399-3089.2003.02078.x
PMID : 12795685

Journal ISSN0908-665X

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Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons

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