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Title

Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons

Authors
Teranishi, Katsuhito
Alwayn, Ian P J
Gollackner, Bernd
Knosalla, Christoph
Huck, Jennifer
Duthaler, Rudolf
Katopodis, Andreas
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Published in Xenotransplantation. 2003, vol. 10, no. 4, p. 357-67
Abstract Natural anti-Gal antibodies (NAb) to Gal epitopes play a key role in the rejection of pig cells or organs transplanted into primates. We have investigated the effect on NAb return after extracorporeal immunoadsorption (EIA) of the continuous intravenous (i.v.) infusion of (i) bovine serum albumin conjugated to Gal type 6 oligosaccharides (BSA-Gal) or (ii) a poly l-lysine backbone conjugated to Gal type 2 or 6 oligosaccharides (PLL-Gal).
Keywords AnimalsAntibodies, Heterophile/blood/immunologyGalactose/immunologyGlycoconjugates/immunology/pharmacologyGraft Rejection/immunology/mortality/pathologyHematopoiesis/immunologyHematopoietic Stem Cell TransplantationImmune Tolerance/immunologyIntestine, Small/pathologyLung/pathologyMyocardium/pathologyPapioSerum Albumin, Bovine/pharmacologySurvival RateSwine, MiniatureTransplantation ChimeraTransplantation, Heterologous/immunology
Identifiers
PMID: 12795685
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Structures
Research group Cultures cellulaires et transplantations (519)
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TERANISHI, Katsuhito et al. Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons. In: Xenotransplantation, 2003, vol. 10, n° 4, p. 357-67. https://archive-ouverte.unige.ch/unige:45479

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Deposited on : 2015-01-19

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