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L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction

Russmann, H
Ghika, J
Combrement, P
Bogousslavsky, J
Published in Neurology. 2004, vol. 63, no. 1, p. 153-5
Abstract The authors studied the long-term evolution of levodopa-induced dyskinesia (LID) after levodopa challenge in two groups of six STN-deep brain stimulation-treated Parkinson disease (PD) patients, one requiring medication after surgery and the other not. A dramatic (96%) reduction of LID severity was obtained in the six postoperatively untreated patients compared to a moderate improvement (47%) in the treated group (p < 0.03). These data support dopaminergic stimulation and striatal desensitization as major determinants of LID in PD.
Keywords AgedAged, 80 and overAntiparkinson Agents/administration & dosage/adverse effects/diagnostic use/therapeutic useCombined Modality TherapyCorpus Striatum/physiopathologyDeep Brain StimulationDose-Response Relationship, DrugDyskinesia, Drug-Induced/etiology/physiopathologyFemaleHumansLevodopa/administration & dosage/adverse effects/diagnostic use/therapeutic useMaleMiddle AgedParkinson Disease/drug therapy/therapyReceptors, Dopamine/drug effectsSeverity of Illness Index
PMID: 15249627
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Research group Groupe Pierre Burkhard (neurologie) (154)
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RUSSMANN, H et al. L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction. In: Neurology, 2004, vol. 63, n° 1, p. 153-5. doi: 10.1212/01.WNL.0000131910.72829.9D https://archive-ouverte.unige.ch/unige:45356

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Deposited on : 2015-01-15

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