Scientific article

L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction

Published inNeurology, vol. 63, no. 1, p. 153-155
Publication date2004

The authors studied the long-term evolution of levodopa-induced dyskinesia (LID) after levodopa challenge in two groups of six STN-deep brain stimulation-treated Parkinson disease (PD) patients, one requiring medication after surgery and the other not. A dramatic (96%) reduction of LID severity was obtained in the six postoperatively untreated patients compared to a moderate improvement (47%) in the treated group (p < 0.03). These data support dopaminergic stimulation and striatal desensitization as major determinants of LID in PD.

  • Aged
  • Aged, 80 and over
  • Antiparkinson Agents/administration & dosage/adverse effects/diagnostic use/therapeutic use
  • Combined Modality Therapy
  • Corpus Striatum/physiopathology
  • Deep Brain Stimulation
  • Dose-Response Relationship, Drug
  • Dyskinesia, Drug-Induced/etiology/physiopathology
  • Female
  • Humans
  • Levodopa/administration & dosage/adverse effects/diagnostic use/therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease/drug therapy/therapy
  • Receptors, Dopamine/drug effects
  • Severity of Illness Index
Citation (ISO format)
RUSSMANN, H et al. L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction. In: Neurology, 2004, vol. 63, n° 1, p. 153–155. doi: 10.1212/01.WNL.0000131910.72829.9D
Main files (1)
Article (Published version)
ISSN of the journal0028-3878

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