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Mécanismes pathogéniques des maladies neurodégénératives : l'exemple de la sclérose latérale amyotrophique

Authors
Kuntzer, T
Published in Revue médicale suisse. 2006, vol. 2, no. 64, p. 1152-4,1156-7
Abstract Since its description by Charcot in 1869, the mechanism underlying the characteristic selective degeneration and death of motor neurons in amyotrophic lateral sclerosis (ALS) has remained a mystery. There is no effective remedy for this progressive, fatal disorder. Modern genetics have now identified two genes, SODI and ALS2 as primary causes of the disease and has implicated others as potential contributors. These insights have enabled development of model systems to test hypotheses of disease mechanism and potential therapies. Along with errors in the handling of synaptic glutamate and the potential excitotoxic response that it provokes, these model systems underscore the involvement of non-neuronal cells in disease progression and provide new therapeutic strategies.
Keywords Amyotrophic Lateral Sclerosis/etiologyHumans
Identifiers
PMID: 16734186
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Research group Groupe Pierre Burkhard (neurologie) (154)
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KATO, Ann Catherine et al. Mécanismes pathogéniques des maladies neurodégénératives : l'exemple de la sclérose latérale amyotrophique. In: Revue médicale suisse, 2006, vol. 2, n° 64, p. 1152-4,1156-7. https://archive-ouverte.unige.ch/unige:45346

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Deposited on : 2015-01-15

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