Scientific article
Case report

Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine

Published inEuropean journal of cardio-thoracic surgery, vol. 24, no. 2, p. 325-327
Publication date2003

Immunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.

  • Anaphylaxis/chemically induced
  • Aorta/surgery
  • Aortic Aneurysm/surgery
  • Blood Vessel Prosthesis Implantation
  • Cardiopulmonary Bypass
  • Fatal Outcome
  • Heart-Assist Devices
  • Heparin Antagonists/adverse effects
  • Humans
  • Male
  • Middle Aged
  • Postoperative Complications/chemically induced
  • Protamines/adverse effects
Citation (ISO format)
PANOS, Aristotelis et al. Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine. In: European journal of cardio-thoracic surgery, 2003, vol. 24, n° 2, p. 325–327. doi: 10.1016/S1010-7940(03)00252-5
Main files (1)
Article (Published version)
ISSN of the journal1010-7940

Technical informations

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