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Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine

Published in European journal of cardio-thoracic surgery. 2003, vol. 24, no. 2, p. 325-7
Abstract Immunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.
Keywords Anaphylaxis/chemically inducedAorta/surgeryAortic Aneurysm/surgeryBlood Vessel Prosthesis ImplantationCardiopulmonary BypassFatal OutcomeHeart-Assist DevicesHeparin Antagonists/adverse effectsHumansMaleMiddle AgedPostoperative Complications/chemically inducedProtamines/adverse effects
PMID: 12895638
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Research group Chirurgie cardio-vasculaire (105)
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PANOS, Aristotelis et al. Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine. In: European journal of cardio-thoracic surgery, 2003, vol. 24, n° 2, p. 325-7. doi: 10.1016/S1010-7940(03)00252-5 https://archive-ouverte.unige.ch/unige:45337

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Deposited on : 2015-01-15

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