Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

Pichler, Irene; Del Greco M, Fabiola; Gögele, Martin; Lill, Christina M; Bertram, Lars; Do, Chuong B; Eriksson, Nicholas; Foroud, Tatiana; Myers, Richard H; Nalls, Michael; Keller, Margaux F; Benyamin, Beben; Whitfield, John B; Pramstaller, Peter

doi:10.1371/journal.pmed.1001462

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Title		Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study
Authors		Pichler, Irene Del Greco M, Fabiola Gögele, Martin Lill, Christina M Bertram, Lars Do, Chuong B Eriksson, Nicholas Foroud, Tatiana Myers, Richard H Nalls, Michael Keller, Margaux F Benyamin, Beben Whitfield, John B Pramstaller, Peter show all authors [1 - 14]
Collaboration		International Parkinson's Disease Genomics Consortium With : Pollak, Pierre
Published in		PLOS Medicine. 2013, vol. 10, no. 6, p. e1001462
Abstract		Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. We performed a MR study where genes known to modify iron levels were used as instruments to estimate the effect of iron on PD risk, based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date.
Keywords		Genetic Association Studies — Genetic Predisposition to Disease — Humans — Iron/blood — Mendelian Randomization Analysis — Parkinson Disease/blood/genetics — Risk Factors
Identifiers		DOI: 10.1371/journal.pmed.1001462 PMID: 23750121
Full text		Article (Published version) (561 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Maladie de Parkinson (911)
Citation (ISO format)		PICHLER, Irene et al. Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. In: PLOS Medicine, 2013, vol. 10, n° 6, p. e1001462. doi: 10.1371/journal.pmed.1001462 https://archive-ouverte.unige.ch/unige:45252