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Scientific article
Open access
English

Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

CollaboratorsPollak, Pierre
Published inPLoS medicine, vol. 10, no. 6, e1001462
Publication date2013
Abstract

Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. We performed a MR study where genes known to modify iron levels were used as instruments to estimate the effect of iron on PD risk, based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date.

Keywords
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Iron/blood
  • Mendelian Randomization Analysis
  • Parkinson Disease/blood/genetics
  • Risk Factors
Citation (ISO format)
PICHLER, Irene et al. Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. In: PLoS medicine, 2013, vol. 10, n° 6, p. e1001462. doi: 10.1371/journal.pmed.1001462
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1549-1277
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