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Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

Pichler, Irene
Del Greco M, Fabiola
Gögele, Martin
Lill, Christina M
Bertram, Lars
Do, Chuong B
Eriksson, Nicholas
Foroud, Tatiana
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CollaborationWith : Pollak, Pierre
Published in PLOS Medicine. 2013, vol. 10, no. 6, p. e1001462
Abstract Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. We performed a MR study where genes known to modify iron levels were used as instruments to estimate the effect of iron on PD risk, based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date.
Keywords Genetic Association StudiesGenetic Predisposition to DiseaseHumansIron/bloodMendelian Randomization AnalysisParkinson Disease/blood/geneticsRisk Factors
PMID: 23750121
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Research group Maladie de Parkinson (911)
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PICHLER, Irene et al. Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. In: PLOS Medicine, 2013, vol. 10, n° 6, p. e1001462. doi: 10.1371/journal.pmed.1001462 https://archive-ouverte.unige.ch/unige:45252

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Deposited on : 2015-01-14

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