Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

Lesage, S; Condroyer, C; Lannuzel, A; Lohmann, E; Troiano, A; Tison, F; Damier, P; Thobois, S; Ouvrard-Hernandez, A-M; Rivaud-Péchoux, S; Brefel-Courbon, C; Destée, A; Tranchant, C; Romana, M; Leclere, L; Dürr, A; Brice, A; French Parkinson's Disease Genetics Study Group

doi:10.1136/jmg.2008.062612

Scientific article

Letter

English

Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

ContributorsLesage, S; Condroyer, C; Lannuzel, A; Lohmann, E; Troiano, A; Tison, F; Damier, P; Thobois, S; Ouvrard-Hernandez, A-M; Rivaud-Péchoux, S; Brefel-Courbon, C; Destée, A; Tranchant, C; Romana, M; Leclere, L; Dürr, A; Brice, A; French Parkinson's Disease Genetics Study Group

CollaboratorsPollak, Pierre

Published inJournal of medical genetics, vol. 46, no. 7, p. 458-464

Publication date2009

Abstract

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (ADPD), the most common of which is the p.G2019S substitution that has been found at varying frequencies worldwide. Because of the size of the LRRK2 gene, few studies have analysed the entire gene in large series of ADPD families.

Keywords

Adolescent
Adult
African Continental Ancestry Group/genetics
Aged
Aged, 80 and over
Analysis of Variance
Chi-Square Distribution
DNA Mutational Analysis/methods
European Continental Ancestry Group/genetics
Female
Gene Frequency
Humans
Male
Middle Aged
Mutation
Parkinsonian Disorders/diagnosis/genetics
Pedigree
Protein-Serine-Threonine Kinases/genetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Maladie de Parkinson (911)

Citation (ISO format)

LESAGE, S et al. Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson’s disease. In: Journal of medical genetics, 2009, vol. 46, n° 7, p. 458–464. doi: 10.1136/jmg.2008.062612

Article (Published version)

Identifiers

PID : unige:45251
DOI : 10.1136/jmg.2008.062612
PMID : 19357115

Journal ISSN0022-2593

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Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

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