Follow-up study of the GIGYF2 gene in French families with Parkinson's disease

Lesage, Suzanne; Condroyer, Christel; Lohman, Ebba; Troiano, André; Tison, François; Viallet, François; Damier, Philippe; Tranchant, Christine; Vidhaillet, Marie; Ouvrard-Hernandez, Anne-Marie; Dürr, Alexandra; Brice, Alexis; French Parkinson's Disease Genetics Study Group (FPDGSG)

doi:10.1016/j.neurobiolaging.2009.06.008

Scientific article

English

Follow-up study of the GIGYF2 gene in French families with Parkinson's disease

Contributors

Lesage, Suzanne; Condroyer, Christel; Lohman, Ebba; Troiano, André; Tison, François; Viallet, François; Damier, Philippe; Tranchant, Christine; Vidhaillet, Marie; Ouvrard-Hernandez, Anne-Marie; Dürr, Alexandra; Brice, Alexis; French Parkinson's Disease Genetics Study Group (FPDGSG)

Collaborators

Pollak, Pierre

Published in

Neurobiology of aging, vol. 31, no. 6, p. 1069-1071;discussion1072-4

Publication date

2010

Abstract

Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.

Keywords

Adult
Aged
Aged, 80 and over
Carrier Proteins/genetics
Family Health
Female
Follow-Up Studies
France
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged
Parkinson Disease/genetics
Young Adult

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

UNIGE research groups

Maladie de Parkinson (911)

Citation (ISO format)

LESAGE, Suzanne et al. Follow-up study of the GIGYF2 gene in French families with Parkinson’s disease. In: Neurobiology of aging, 2010, vol. 31, n° 6, p. 1069–1071;discussion1072–4. doi: 10.1016/j.neurobiolaging.2009.06.008

Article (Published version)

Identifiers

PID : unige:45246
DOI : 10.1016/j.neurobiolaging.2009.06.008
PMID : 20004041

Journal ISSN

0197-4580

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10/11/2026 17:15:09

Follow-up study of the GIGYF2 gene in French families with Parkinson's disease

Contributors

Collaborators

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation