en
Scientific article
English

Follow-up study of the GIGYF2 gene in French families with Parkinson's disease

CollaboratorsPollak, Pierre
Published inNeurobiology of aging, vol. 31, no. 6, p. 1069-1071;discussion1072-4
Publication date2010
Abstract

Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Carrier Proteins/genetics
  • Family Health
  • Female
  • Follow-Up Studies
  • France
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease/genetics
  • Young Adult
Citation (ISO format)
LESAGE, Suzanne et al. Follow-up study of the GIGYF2 gene in French families with Parkinson’s disease. In: Neurobiology of aging, 2010, vol. 31, n° 6, p. 1069–1071;discussion1072–4. doi: 10.1016/j.neurobiolaging.2009.06.008
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0197-4580
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