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Follow-up study of the GIGYF2 gene in French families with Parkinson's disease

Lesage, Suzanne
Condroyer, Christel
Lohman, Ebba
Troiano, André
Tison, François
Viallet, François
Damier, Philippe
Tranchant, Christine
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CollaborationWith : Pollak, Pierre
Published in Neurobiology of aging. 2010, vol. 31, no. 6, p. 1069-71;discussion1072-4
Abstract Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.
Keywords AdultAgedAged, 80 and overCarrier Proteins/geneticsFamily HealthFemaleFollow-Up StudiesFranceGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedParkinson Disease/geneticsYoung Adult
PMID: 20004041
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Research group Maladie de Parkinson (911)
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LESAGE, Suzanne et al. Follow-up study of the GIGYF2 gene in French families with Parkinson's disease. In: Neurobiology of aging, 2010, vol. 31, n° 6, p. 1069-71;discussion1072-4. doi: 10.1016/j.neurobiolaging.2009.06.008 https://archive-ouverte.unige.ch/unige:45246

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Deposited on : 2015-01-14

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