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Title

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

Authors
Ross, Owen A
Soto-Ortolaza, Alexandra I
Heckman, Michael G
Aasly, Jan O
Abahuni, Nadine
Annesi, Grazia
Bacon, Justin A
Bardien, Soraya
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CollaborationWith : Pollak, Pierre
Published in The Lancet Neurology. 2011, vol. 10, no. 10, p. 898-908
Abstract Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the variants in PD susceptibility.
Keywords AdolescentAdultAgedAged, 80 and overCase-Control StudiesEthnic Groups/geneticsExons/geneticsFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association Study/methodsGenotypeHumansInternational CooperationMaleMiddle AgedParkinson Disease/geneticsPolymorphism, Single Nucleotide/geneticsProtein-Serine-Threonine Kinases/geneticsRisk FactorsYoung Adult
Identifiers
PMID: 21885347
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Article (Published version) (498 Kb) - public document Free access
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Research group Maladie de Parkinson (911)
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ROSS, Owen A et al. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. In: The Lancet Neurology, 2011, vol. 10, n° 10, p. 898-908. https://archive-ouverte.unige.ch/unige:45235

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Deposited on : 2015-01-14

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