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Acute and subacute drug-induced movement disorders

Published in Parkinsonism & Related Disorders. 2014, vol. 20 Suppl 1, p. S108-12
Abstract Many pharmacological agents may induce a variety of movement disorders, including dystonia, tremor, parkinsonism, myoclonus and dyskinesia, with an acute, subacute or more chronic time course. Motor symptoms may be isolated or part of a more extensive cerebral or systemic condition, such as the neuroleptic malignant syndrome or the serotonin syndrome. Drug-induced movement disorders share a number of features that should make them easy to identify, including a clear temporal relationship between medication initiation and symptom onset, a dose-effect, and, with the exception of tardive syndromes, complete resolution after discontinuation of the offending agent. Diagnosis relies on a thorough medication history. Medications commonly involved include dopamine receptor blockers, antidepressants and anti-epileptics, among many others. Mechanisms underlying drug-induced movement disorders involve blockade, facilitation or imbalance of dopamine, serotonin, noradrenaline and cholinergic neurotransmission in the basal ganglia. The present review focuses on drug-induced movement disorders that typically develop as an acute (hours to days) or subacute (days to weeks) event, including acute dystonic reactions, akathisia, drug-induced parkinsonism, neuroleptic malignant syndrome, serotonin syndrome, parkinsonism-hyperpyrexia syndrome, drug-induced tremor, drug-induced hyperkinesias and movement disorders associated with the use of recreational drugs.
Keywords Basal Ganglia/metabolismCentral Nervous System Agents/adverse effectsHumansMovement Disorders/etiology/pathologyNeurotransmitter Agents/metabolismTime Factors
PMID: 24262159
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Research group Groupe Pierre Burkhard (neurologie) (154)
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BURKHARD, Pierre. Acute and subacute drug-induced movement disorders. In: Parkinsonism & Related Disorders, 2014, vol. 20 Suppl 1, p. S108-12. https://archive-ouverte.unige.ch/unige:45229

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Deposited on : 2015-01-14

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