Large-scale replication and heterogeneity in Parkinson disease genetic loci

Sharma, Manu; GEO-PD Consortium

doi:10.1212/WNL.0b013e318264e353

Scientific article

English

Large-scale replication and heterogeneity in Parkinson disease genetic loci

ContributorsSharma, Manu; GEO-PD Consortium

CollaboratorsPollak, Pierre

Published inNeurology, vol. 79, no. 7, p. 659-667

Publication date2012

Abstract

Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

Keywords

Aged
Alleles
Case-Control Studies
Female
Gene Frequency
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Parkinson Disease/genetics
Polymorphism, Single Nucleotide

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Maladie de Parkinson (911)

Citation (ISO format)

SHARMA, Manu. Large-scale replication and heterogeneity in Parkinson disease genetic loci. In: Neurology, 2012, vol. 79, n° 7, p. 659–667. doi: 10.1212/WNL.0b013e318264e353

Article (Published version)

Identifiers

PID : unige:45222
DOI : 10.1212/WNL.0b013e318264e353
PMID : 22786590

Journal ISSN0028-3878

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Large-scale replication and heterogeneity in Parkinson disease genetic loci

Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

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