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Title

Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial

Authors
Moreau, Caroline
Delval, Arnaud
Defebvre, Luc
Dujardin, Kathy
Duhamel, Alain
Petyt, Gregory
Vuillaume, Isabelle
Corvol, Jean-Christophe
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CollaborationWith : Pollak, Pierre
Published in The Lancet Neurology. 2012, vol. 11, no. 7, p. 589-96
Abstract Despite optimum medical management, many patients with Parkinson's disease are incapacitated by gait disorders including freezing of gait. We aimed to assess whether methylphenidate--through its combined action on dopamine and noradrenaline reuptake--would improve gait disorders and freezing of gate in patients with advanced Parkinson's disease without dementia who also received subthalamic nucleus stimulation.
Keywords AgedDeep Brain StimulationDopamine Uptake Inhibitors/therapeutic useDouble-Blind MethodFemaleFranceGait Disorders, Neurologic/etiology/therapyHumansHypokinesia/etiology/therapyMaleMethylphenidate/therapeutic useMiddle AgedParkinson Disease/complications/therapyTreatment Outcome
Identifiers
PMID: 22658702
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Research group Maladie de Parkinson (911)
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MOREAU, Caroline et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. In: The Lancet Neurology, 2012, vol. 11, n° 7, p. 589-96. https://archive-ouverte.unige.ch/unige:45202

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Deposited on : 2015-01-14

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