Scientific article
English

Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial

CollaboratorsPollak, Pierre
Published inLancet neurology, vol. 11, no. 7, p. 589-596
Publication date2012
Abstract

Despite optimum medical management, many patients with Parkinson's disease are incapacitated by gait disorders including freezing of gait. We aimed to assess whether methylphenidate--through its combined action on dopamine and noradrenaline reuptake--would improve gait disorders and freezing of gate in patients with advanced Parkinson's disease without dementia who also received subthalamic nucleus stimulation.

Keywords
  • Aged
  • Deep Brain Stimulation
  • Dopamine Uptake Inhibitors/therapeutic use
  • Double-Blind Method
  • Female
  • France
  • Gait Disorders, Neurologic/etiology/therapy
  • Humans
  • Hypokinesia/etiology/therapy
  • Male
  • Methylphenidate/therapeutic use
  • Middle Aged
  • Parkinson Disease/complications/therapy
  • Treatment Outcome
Citation (ISO format)
MOREAU, Caroline et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson’s disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. In: Lancet neurology, 2012, vol. 11, n° 7, p. 589–596. doi: 10.1016/S1474-4422(12)70106-0
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1474-4422
653views
0downloads

Technical informations

Creation13/01/2015 13:53:00
First validation13/01/2015 13:53:00
Update14/03/2023 22:40:58
Status update14/03/2023 22:40:55
Last indexation30/10/2024 22:13:13
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack