Article (Published version) (384 Kb) - Limited access to UNIGE
EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?
|Published in||Neurobiology of Aging. 2012, vol. 33, no. 9, p. 2233.e1-2233.e5|
|Abstract||Mutations in the eukaryotic translation initiation factor 4-gamma (EIF4G1) gene, encoding a component of the eIF4F translation initiation complex, were recently reported as a possible cause for the autosomal dominant form of Parkinson's disease (PD). Here, we describe the screening of all 31 EIF4G1 coding exons in a series of 251 index cases with autosomal dominant PD, mostly of French origin and in 236 European control subjects. We identified 12 rare coding variants (either nonsynonymous amino acid substitutions or in frame deletions/insertions), including 6 variants present only in cases and 3 in controls. Segregation was possible only for 1 variant (p.E462delInsGK) that was found in 2 affected siblings. In addition, we found 2 previously reported pathogenic variants in 2 isolated patients (p.G686C) and in a control subject (p.R1197W). These data do not support the pathogenicity of several EIF4G1 variants in PD, at least in the French population.|
|Keywords||Adult — Aged — Aged, 80 and over — DNA Mutational Analysis — Eukaryotic Initiation Factor-4G/genetics — European Continental Ancestry Group/genetics — Family Health — Female — France — Genetic Predisposition to Disease/genetics — Humans — Male — Middle Aged — Mutation/genetics — Parkinson Disease/genetics/pathology — Young Adult|
|Research group||Maladie de Parkinson (911)|
|LESAGE, Suzanne et al. EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?. In: Neurobiology of Aging, 2012, vol. 33, n° 9, p. 2233.e1-2233.e5. https://archive-ouverte.unige.ch/unige:45192|