Scientific article

Histologic analysis of the irradiated anal sphincter

Published inDiseases of the colon & rectum, vol. 46, no. 11, p. 1492-1497
Publication date2003

There is accumulating evidence, both quantitative and qualitative, that pelvic irradiation adversely affects anorectal function. However, histologic evidence of sphincter injury has not been demonstrated. This study was designed to perform histologic assessment of collagen deposition and nerve alteration in the internal anal sphincters of rectal cancer patients who underwent abdominoperineal resection after adjuvant chemoradiation therapy and to correlate the degree of histologic changes with the time interval between chemoradiotherapy and abdominoperineal resection.

  • Adult
  • Aged
  • Anal Canal/pathology/radiation effects
  • Analysis of Variance
  • Female
  • Fibrosis/etiology/pathology
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Preoperative Care
  • Proctocolectomy, Restorative/methods
  • Radiotherapy, Adjuvant/adverse effects/methods
  • Rectal Neoplasms/pathology/radiotherapy/surgery
Citation (ISO format)
DA SILVA, Giovanna M et al. Histologic analysis of the irradiated anal sphincter. In: Diseases of the colon & rectum, 2003, vol. 46, n° 11, p. 1492–1497. doi: 10.1097/01.DCR.0000093642.89267.67
Main files (1)
Article (Published version)
ISSN of the journal0012-3706

Technical informations

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