UNIGE document Scientific Article
previous document  unige:45072  next document
add to browser collection
Title

Pharmacokinetics of mycophenolic acid associated with calcineurin inhibitors: long-term monitoring in stable lung recipients with and without cystic fibrosis

Authors
Published in Journal of Heart and Lung Transplantation. 2003, vol. 22, no. 5, p. 587-90
Abstract Pharmacologic interactions and absorption disturbances after transplantation may induce serologic fluctuation of immunosuppression and adversely affect outcome. We present data showing that trough levels of mycophenolic acid decreased by 50% during combined mycophenolate mofetil (MMF) and cyclosporine therapy compared with levels during combined MMF and tacrolimus therapy. In addition, cystic fibrosis patients required 30% higher doses of MMF to achieve the therapeutic levels of recipients without cystic fibrosis.
Keywords AdultCalcineurin InhibitorsCyclosporine/pharmacokinetics/therapeutic useCystic Fibrosis/drug therapy/surgeryDose-Response Relationship, DrugDrug InteractionsDrug Therapy, CombinationHumansImmunosuppressive Agents/pharmacokinetics/therapeutic useLung Transplantation/immunologyMycophenolic Acid/analogs & derivatives/pharmacokinetics/therapeutic useTacrolimus/pharmacokinetics/therapeutic use
Identifiers
PMID: 12742423
Full text
Article (Published version) (79 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Monitoring du programme d'études et de formation pré-graduée de médecine (877)
L'épithélium respiratoire (852)
Citation
(ISO format)
GERBASE, Margaret et al. Pharmacokinetics of mycophenolic acid associated with calcineurin inhibitors: long-term monitoring in stable lung recipients with and without cystic fibrosis. In: Journal of Heart and Lung Transplantation, 2003, vol. 22, n° 5, p. 587-90. https://archive-ouverte.unige.ch/unige:45072

137 hits

0 download

Update

Deposited on : 2015-01-13

Export document
Format :
Citation style :