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Title

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy
Authors
Duarte, João M.N.
Do, Kim Q.
Gruetter, Rolf
Published in Neurobiology of Aging. 2014, vol. 35, no. 7, p. 1660-1668
Abstract Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum of C57BL/6 mice aged between 3 and 24 months . The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline. Interestingly, the neurochemical profile was different in male and female mice, particularly in the levels of taurine that may be under the control of estrogen receptors. These neurochemical profiles constitute the basal concentrations in cortex, hippocampus, and striatum of healthy aging male and female mice.
Identifiers
PMID: 24560998
Full text
Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://linkinghub.elsevier.com/retrieve/pii/S0197458014001572
Structures
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Citation
(ISO format) 		DUARTE, João M.N., DO, Kim Q., GRUETTER, Rolf. Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy. In: Neurobiology of Aging, 2014, vol. 35, n° 7, p. 1660-1668. https://archive-ouverte.unige.ch/unige:45067

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Deposited on : 2015-01-13

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