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Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation

Gollackner, Bernd
Mueller, Nicolas J
Houser, Stuart
Qawi, Imrana
Soizic, Daniel
Knosalla, Christoph
Dor, Frank J M F
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Published in Transplantation. 2003, vol. 75, no. 11, p. 1841-7
Abstract A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or infection, or by molecular incompatibilities between porcine coagulation proteins and primate clotting factors. The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC.
Keywords AnimalsAnimals, Genetically ModifiedCytomegalovirus/genetics/isolation & purificationCytomegalovirus Infections/physiopathologyDNA, Viral/analysisGraft Survival/physiologyImmunosuppressionKidney/pathology/surgeryKidney TransplantationPapioPostoperative Complications/physiopathology/virologySwineSwine, MiniatureThrombocytopenia/physiopathologyTransplantation, Heterologous
PMID: 12811243
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Research group Cultures cellulaires et transplantations (519)
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GOLLACKNER, Bernd et al. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. In: Transplantation, 2003, vol. 75, n° 11, p. 1841-7. doi: 10.1097/01.TP.0000065806.90840.C1 https://archive-ouverte.unige.ch/unige:45063

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Deposited on : 2015-01-13

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