en
Scientific article
English

Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation

Published inTransplantation, vol. 75, no. 11, p. 1841-1847
Publication date2003
Abstract

A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or infection, or by molecular incompatibilities between porcine coagulation proteins and primate clotting factors. The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC.

Keywords
  • Animals
  • Animals, Genetically Modified
  • Cytomegalovirus/genetics/isolation & purification
  • Cytomegalovirus Infections/physiopathology
  • DNA, Viral/analysis
  • Graft Survival/physiology
  • Immunosuppression
  • Kidney/pathology/surgery
  • Kidney Transplantation
  • Papio
  • Postoperative Complications/physiopathology/virology
  • Swine
  • Swine, Miniature
  • Thrombocytopenia/physiopathology
  • Transplantation, Heterologous
Citation (ISO format)
GOLLACKNER, Bernd et al. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. In: Transplantation, 2003, vol. 75, n° 11, p. 1841–1847. doi: 10.1097/01.TP.0000065806.90840.C1
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
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