Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation

Gollackner, Bernd; Mueller, Nicolas J; Houser, Stuart; Qawi, Imrana; Soizic, Daniel; Knosalla, Christoph; Buehler, Leo Hans; Dor, Frank J M F; Awwad, Michel; Sachs, David H; Cooper, David K C; Robson, Simon C; Fishman, Jay A

doi:10.1097/01.TP.0000065806.90840.C1

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Title		Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation
Authors		Gollackner, Bernd Mueller, Nicolas J Houser, Stuart Qawi, Imrana Soizic, Daniel Knosalla, Christoph Buehler, Leo Hans Dor, Frank J M F Awwad, Michel Sachs, David H Cooper, David K C Robson, Simon C Fishman, Jay A show all authors [1 - 13]
Published in		Transplantation. 2003, vol. 75, no. 11, p. 1841-7
Abstract		A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or infection, or by molecular incompatibilities between porcine coagulation proteins and primate clotting factors. The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC.
Keywords		Animals — Animals, Genetically Modified — Cytomegalovirus/genetics/isolation & purification — Cytomegalovirus Infections/physiopathology — DNA, Viral/analysis — Graft Survival/physiology — Immunosuppression — Kidney/pathology/surgery — Kidney Transplantation — Papio — Postoperative Complications/physiopathology/virology — Swine — Swine, Miniature — Thrombocytopenia/physiopathology — Transplantation, Heterologous
Identifiers		DOI: 10.1097/01.TP.0000065806.90840.C1 PMID: 12811243
Full text		Article (Published version) (519 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		Cultures cellulaires et transplantations (519)
Citation (ISO format)		GOLLACKNER, Bernd et al. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. In: Transplantation, 2003, vol. 75, n° 11, p. 1841-7. doi: 10.1097/01.TP.0000065806.90840.C1 https://archive-ouverte.unige.ch/unige:45063