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Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Öz, Gülin
Published in Radiology. 2014, vol. 270, no. 3, p. 658-679
Abstract A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of (1)H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of (1)H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which (1)H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.
PMID: 24568703
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Research group L'imagerie cérébrale (184)
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ÖZ, Gülin, GRUETTER, Rolf, HÜPPI, Petra Susan. Clinical Proton MR Spectroscopy in Central Nervous System Disorders. In: Radiology, 2014, vol. 270, n° 3, p. 658-679. doi: 10.1148/radiol.13130531 https://archive-ouverte.unige.ch/unige:44998

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Deposited on : 2015-01-12

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