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Title

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
Authors
Assal, Frédéric
Alarcón, Maricela
Solomon, Esther C
Masterman, Donna
Geschwind, Daniel H
Cummings, Jeffrey L
Published in Archives of Neurology. 2004, vol. 61, no. 8, p. 1249-53
Abstract Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.
Keywords Aged — Aged, 80 and over — Alzheimer Disease/genetics/psychology — Analysis of Variance — Carrier Proteins/genetics — Female — Humans — Male — Membrane Glycoproteins/genetics — Membrane Transport Proteins — Nerve Tissue Proteins/genetics — Polymorphism, Genetic/genetics — Receptor, Serotonin, 5-HT2A/genetics — Receptors, Serotonin/genetics — Serotonin Plasma Membrane Transport Proteins
Identifiers
PMID: 15313842
Full text
Article (Published version) (85 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group Neuropsychologie et neurologie comportementale (951)
Citation
(ISO format) 		ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of Neurology, 2004, vol. 61, n° 8, p. 1249-53. https://archive-ouverte.unige.ch/unige:44941

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Deposited on : 2015-01-12

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