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Scientific article
English

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

Published inArchives of neurology, vol. 61, no. 8, p. 1249-1253
Publication date2004
Abstract

Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.

Keywords
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/genetics/psychology
  • Analysis of Variance
  • Carrier Proteins/genetics
  • Female
  • Humans
  • Male
  • Membrane Glycoproteins/genetics
  • Membrane Transport Proteins
  • Nerve Tissue Proteins/genetics
  • Polymorphism, Genetic/genetics
  • Receptor, Serotonin, 5-HT2A/genetics
  • Receptors, Serotonin/genetics
  • Serotonin Plasma Membrane Transport Proteins
Citation (ISO format)
ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of neurology, 2004, vol. 61, n° 8, p. 1249–1253. doi: 10.1001/archneur.61.8.1249
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Article (Published version)
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ISSN of the journal0003-9942
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