Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

Assal, Frédéric; Alarcón, Maricela; Solomon, Esther C; Masterman, Donna; Geschwind, Daniel H; Cummings, Jeffrey L

doi:10.1001/archneur.61.8.1249

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Title		Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
Authors		Assal, Frédéric Alarcón, Maricela Solomon, Esther C Masterman, Donna Geschwind, Daniel H Cummings, Jeffrey L
Published in		Archives of Neurology. 2004, vol. 61, no. 8, p. 1249-53
Abstract		Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.
Keywords		Aged — Aged, 80 and over — Alzheimer Disease/genetics/psychology — Analysis of Variance — Carrier Proteins/genetics — Female — Humans — Male — Membrane Glycoproteins/genetics — Membrane Transport Proteins — Nerve Tissue Proteins/genetics — Polymorphism, Genetic/genetics — Receptor, Serotonin, 5-HT2A/genetics — Receptors, Serotonin/genetics — Serotonin Plasma Membrane Transport Proteins
Identifiers		DOI: 10.1001/archneur.61.8.1249 PMID: 15313842
Full text		Article (Published version) (85 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Neuropsychologie et neurologie comportementale (951)
Citation (ISO format)		ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of Neurology, 2004, vol. 61, n° 8, p. 1249-53. doi: 10.1001/archneur.61.8.1249 https://archive-ouverte.unige.ch/unige:44941