Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

Assal, Frédéric; Alarcón, Maricela; Solomon, Esther C; Masterman, Donna; Geschwind, Daniel H; Cummings, Jeffrey L

doi:10.1001/archneur.61.8.1249

Scientific article

English

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

ContributorsAssal, Frédéric; Alarcón, Maricela; Solomon, Esther C; Masterman, Donna; Geschwind, Daniel H; Cummings, Jeffrey L

Published inArchives of neurology, vol. 61, no. 8, p. 1249-1253

Publication date2004

Abstract

Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.

Keywords

Aged
Aged, 80 and over
Alzheimer Disease/genetics/psychology
Analysis of Variance
Carrier Proteins/genetics
Female
Humans
Male
Membrane Glycoproteins/genetics
Membrane Transport Proteins
Nerve Tissue Proteins/genetics
Polymorphism, Genetic/genetics
Receptor, Serotonin, 5-HT2A/genetics
Receptors, Serotonin/genetics
Serotonin Plasma Membrane Transport Proteins

Affiliation

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research group

Neuropsychologie et neurologie comportementale (951)

Citation (ISO format)

ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of neurology, 2004, vol. 61, n° 8, p. 1249–1253. doi: 10.1001/archneur.61.8.1249

Article (Published version)

Identifiers

PID : unige:44941
DOI : 10.1001/archneur.61.8.1249
PMID : 15313842

ISSN of the journal0003-9942

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Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

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