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Title

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

Authors
Alarcón, Maricela
Solomon, Esther C
Masterman, Donna
Geschwind, Daniel H
Cummings, Jeffrey L
Published in Archives of Neurology. 2004, vol. 61, no. 8, p. 1249-53
Abstract Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.
Keywords AgedAged, 80 and overAlzheimer Disease/genetics/psychologyAnalysis of VarianceCarrier Proteins/geneticsFemaleHumansMaleMembrane Glycoproteins/geneticsMembrane Transport ProteinsNerve Tissue Proteins/geneticsPolymorphism, Genetic/geneticsReceptor, Serotonin, 5-HT2A/geneticsReceptors, Serotonin/geneticsSerotonin Plasma Membrane Transport Proteins
Identifiers
PMID: 15313842
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Research group Neuropsychologie et neurologie comportementale (951)
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(ISO format)
ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of Neurology, 2004, vol. 61, n° 8, p. 1249-53. https://archive-ouverte.unige.ch/unige:44941

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Deposited on : 2015-01-12

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