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Scientific article
English

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

ContributorsAssal, Frédéric; Alarcón, Maricela; Solomon, Esther C; Masterman, Donna; Geschwind, Daniel H; Cummings, Jeffrey L
Published inArchives of neurology, vol. 61, no. 8, p. 1249-1253
Publication date2004
Abstract

Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.

Keywords
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/genetics/psychology
  • Analysis of Variance
  • Carrier Proteins/genetics
  • Female
  • Humans
  • Male
  • Membrane Glycoproteins/genetics
  • Membrane Transport Proteins
  • Nerve Tissue Proteins/genetics
  • Polymorphism, Genetic/genetics
  • Receptor, Serotonin, 5-HT2A/genetics
  • Receptors, Serotonin/genetics
  • Serotonin Plasma Membrane Transport Proteins
Affiliation entities
Research groups
Citation (ISO format)
ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of neurology, 2004, vol. 61, n° 8, p. 1249–1253. doi: 10.1001/archneur.61.8.1249
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0003-9942
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Creation05/12/2014 14:42:00
First validation05/12/2014 14:42:00
Update14/03/2023 22:38:42
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