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Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease |
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Published in | Archives of Neurology. 2004, vol. 61, no. 8, p. 1249-53 | |
Abstract | Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies. | |
Keywords | Aged — Aged, 80 and over — Alzheimer Disease/genetics/psychology — Analysis of Variance — Carrier Proteins/genetics — Female — Humans — Male — Membrane Glycoproteins/genetics — Membrane Transport Proteins — Nerve Tissue Proteins/genetics — Polymorphism, Genetic/genetics — Receptor, Serotonin, 5-HT2A/genetics — Receptors, Serotonin/genetics — Serotonin Plasma Membrane Transport Proteins | |
Identifiers | PMID: 15313842 | |
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Research group | Neuropsychologie et neurologie comportementale (951) | |
Citation (ISO format) | ASSAL, Frédéric et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. In: Archives of Neurology, 2004, vol. 61, n° 8, p. 1249-53. doi: 10.1001/archneur.61.8.1249 https://archive-ouverte.unige.ch/unige:44941 |