• Home
  1. Home
  2. Pharmacological interventions in primary care: hopes and illusions
Scientific article
Review
English

Pharmacological interventions in primary care: hopes and illusions

Contributors

Assal, Frédéric; Van Der Meulen, Marian

Published in

Frontiers of neurology and neuroscience, vol. 24, p. 54-65

Publication date

2009

Abstract

Alzheimer's disease is a neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, synaptic loss, neuronal death and cholinergic deficits, causing cognitive, behavioral and psychological deficits, as well as a functional impairment that results in serious caregiver distress and a great economic burden worldwide. High hopes rose with the development of symptomatic treatments,resulting from randomized controlled trials using cholinergic enhancers or cholinesterase inhibitors, such as donepezil, galantamine and rivastigmine. When memantine, an NMDA antagonist,was approved and the first phase III antiamyloid immunization was launched, many clinicians eagerly anticipated the first disease-modifying drugs in their daily practice. For the treatment of behavioral and psychological symptoms of dementia (BPSD), atypical antipsychotics and new-generation antidepressants also seemed to offer great promises, mainly because of their good tolerance and side effect profiles. Hopes, however, were followed by desillusions: subsequent studies demonstrated that cholinesterase inhibitors and memantine had only modest and short-lived effects on cognition and BPSD, and the effect of antipsychotics on BPSD appeared questionable. Disease-modifying drugs such as antiamyloid immunization or amyloid clearance medication had to be abandoned for safety reasons or absence of efficacy. Although the early treatment of vascular risk factors is increasingly recognized in Alzheimer's disease prevention because of their implication in the amyloid cascade, randomized controlled trials have yielded largely negative results. Therefore,pharmacological as well as fundamental research that better underpins the complex pathophysiology of this devastating disease constitutes one of the biggest challenges of the 21st century.

Keywords

  • Alzheimer Disease/drug therapy
  • Clinical Trials as Topic
  • Humans
  • Primary Health Care/methods

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

ASSAL, Frédéric, VAN DER MEULEN, Marian. Pharmacological interventions in primary care: hopes and illusions. In: Frontiers of neurology and neuroscience, 2009, vol. 24, p. 54–65. doi: 10.1159/000197884

Identifiers

Journal ISSN

0300-5186
611views
0downloads

Technical informations

Creation

05/12/2014 14:20:00

First validation

05/12/2014 14:20:00

Update

14/03/2023 22:38:41

Status update

14/03/2023 22:38:41

Last indexation

30/10/2024 22:05:57
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated