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Title

The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG)

Authors
Betts, David R
Ammann, Roland A
Hirt, Andreas
Hengartner, Heinz
Beck-Popovic, Maja
Kuhne, Thomas
Nobile, Luisa
Caflisch, Ueli
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Published in European Journal of Haematology. 2007, vol. 78, no. 6, p. 468-76
Abstract In childhood-onset acute myeloid leukaemia (AML) the clinical value of karyotypic aberrations is now acknowledged, although there is still debate concerning the prognostic significance of some events. To add to this knowledge, cytogenetic analysis was performed on a consecutive series of 84 childhood AML patients diagnosed in Switzerland. A result was obtained for all patients, with 69 (82%) showing a clonal karyotypic aberration. In the remaining 15 (18%), no karyotypic aberration was seen by either conventional or fluorescence in situ hybridisation analyses. The most frequent aberrations observed were t(11q23) (19% of all patients), t(8;21) (12%) and +8 (11%). Except for cytogenetics, no clinical parameter was shown to be significantly associated with outcome. The analysis of individual cytogenetic subgroups demonstrated that aberrations involving chromosome 16q were the strongest predictor of a good prognosis, while +8 and complex karyotypes represented the strongest predictors of a poor prognosis. It was also noteworthy that patients with the rare aberrations of del(11q) (n = 4) and t(16;21)(p11;q22) (n = 3) had a poor outcome. The results support the importance of cytogenetic analysis in childhood AML, but show that further work is required in the classification of the poor prognosis aberrations.
Keywords Acute DiseaseAdolescentChildChild, PreschoolChromosome AberrationsFemaleHumansIn Situ Hybridization, FluorescenceIncidenceKaryotypingLeukemia, Myeloid/geneticsMalePrognosisRemission InductionSurvival Analysis
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PMID: 17419750
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BETTS, David R et al. The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG). In: European Journal of Haematology, 2007, vol. 78, n° 6, p. 468-76. https://archive-ouverte.unige.ch/unige:44922

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Deposited on : 2015-01-12

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