A survey of FDG- and amyloid-PET imaging in dementia and GRADE analysis

Perani, Daniela; Daniela, Perani; Schillaci, Orazio; Orazio, Schillaci; Padovani, Alessandro; Alessandro, Padovani; Nobili, Flavio Mariano; Mariano, Nobili Flavio; Iaccarino, Leonardo; Leonardo, Iaccarino; Della Rosa, Pasquale Anthony; Pasquale Anthony, Della Rosa; Giovanni, Frisoni; Caltagirone, Carlo; Carlo, Caltagirone; Frisoni, Giovanni

doi:10.1155/2014/785039

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Title		A survey of FDG- and amyloid-PET imaging in dementia and GRADE analysis
Authors		Perani, Daniela Daniela, Perani Schillaci, Orazio Orazio, Schillaci Padovani, Alessandro Alessandro, Padovani Nobili, Flavio Mariano Mariano, Nobili Flavio Iaccarino, Leonardo Leonardo, Iaccarino Della Rosa, Pasquale Anthony Pasquale Anthony, Della Rosa Giovanni, Frisoni Caltagirone, Carlo Carlo, Caltagirone Frisoni, Giovanni show all authors [1 - 16]
Published in		BioMed Research International. 2014, vol. 2014, 785039
Abstract		PET based tools can improve the early diagnosis of Alzheimer's disease (AD) and differential diagnosis of dementia. The importance of identifying individuals at risk of developing dementia among people with subjective cognitive complaints or mild cognitive impairment has clinical, social, and therapeutic implications. Within the two major classes of AD biomarkers currently identified, that is, markers of pathology and neurodegeneration, amyloid- and FDG-PET imaging represent decisive tools for their measurement. As a consequence, the PET tools have been recognized to be of crucial value in the recent guidelines for the early diagnosis of AD and other dementia conditions. The references based recommendations, however, include large PET imaging literature based on visual methods that greatly reduces sensitivity and specificity and lacks a clear cut-off between normal and pathological findings. PET imaging can be assessed using parametric or voxel-wise analyses by comparing the subject's scan with a normative data set, significantly increasing the diagnostic accuracy. This paper is a survey of the relevant literature on FDG and amyloid-PET imaging aimed at providing the value of quantification for the early and differential diagnosis of AD. This allowed a meta-analysis and GRADE analysis revealing high values for PET imaging that might be useful in considering recommendations.
Identifiers		DOI: 10.1155/2014/785039 PMID: 24772437
Full text		Article (Published version) (1.5 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		PERANI, Daniela et al. A survey of FDG- and amyloid-PET imaging in dementia and GRADE analysis. In: BioMed research international, 2014, vol. 2014, p. 785039. doi: 10.1155/2014/785039 https://archive-ouverte.unige.ch/unige:44743