Scientific article

Radiation-induced craniofacial bone growth disturbances

Published inThe Journal of craniofacial surgery, vol. 18, no. 5, p. 1001-1007
Publication date2007

Multimodality treatment, including radiotherapy, chemotherapy, and surgery, is required for the management of head and neck cancer in pediatric patients. Despite the modern advances in radiation dosing and targeting techniques, the radiation damage to the growing craniofacial skeleton in children remains a significant clinical problem. The first part of this review summarizes the clinical effects of radiotherapy on craniofacial bone growth in children. Experimental evidence on therapeutic radiation effects on bone growth in in vivo and in vitro models is reviewed. The second part of this review focuses on prevention of radiation-induced craniofacial bone growth inhibition using radioprotective agents.

  • Facial Bones/drug effects/growth & development/radiation effects
  • Head and Neck Neoplasms/radiotherapy
  • Humans
  • Osteitis/drug therapy/etiology
  • Osteoblasts/radiation effects
  • Radiation Injuries/drug therapy/prevention & control
  • Skull/drug effects/growth & development/radiation effects
Citation (ISO format)
GEVORGYAN, Artur et al. Radiation-induced craniofacial bone growth disturbances. In: The Journal of craniofacial surgery, 2007, vol. 18, n° 5, p. 1001–1007. doi: 10.1097/scs.0b013e31812f7584
Main files (1)
Article (Published version)
ISSN of the journal1049-2275

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