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Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes

Contributors

Fumeaux, Zina; Beris, Photis; Borisch, Bettina; Sarasin, François P; Roosnek, Eddy Emile; Dayer, Jean-Michel; Chizzolini, Carlo

Published in

European journal of haematology, vol. 70, no. 3, p. 186-189

Publication date

2003

Abstract

Pure white cell aplasia (PWCA) is a rare disorder of unknown origin, often associated with thymoma, characterized by selective neutropenia or pure agranulocytosis, and absence of granulocyte precursors in the bone marrow, but with normal erythroblasts and megakaryocytes. We report a case of PWCA associated with thymoma. Unusual findings in this case report included simultaneous presence of autoimmune thyroiditis, type 1 diabetes, anti-striated muscle antibodies, and the presence in the peripheral blood of CD8+ T cells that expressed a homogeneous naive phenotype. Neutrophil count became normal on immunosuppressive therapy after thymectomy.

Keywords

  • Aged
  • Agranulocytosis/complications/immunology/therapy
  • Autoantibodies/blood
  • CD8-Positive T-Lymphocytes/immunology/pathology
  • Diabetes Mellitus, Type 1/complications/therapy
  • Female
  • Humans
  • Immunosuppression
  • Leukopenia/complications/immunology/therapy
  • Muscle, Skeletal/immunology
  • Remission Induction
  • Thymectomy
  • Thymoma/complications/therapy
  • Thyroiditis, Autoimmune/complications/therapy

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

FUMEAUX, Zina et al. Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes. In: European journal of haematology, 2003, vol. 70, n° 3, p. 186–189. doi: 10.1034/j.1600-0609.2003.00023.x

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Article (Published version)

Identifiers

Journal ISSN

0902-4441
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264downloads

Technical informations

Creation

09/12/2014 13:15:00

First validation

09/12/2014 13:15:00

Update

30/03/2023 10:31:11

Status update

30/03/2023 10:31:11

Last indexation

30/10/2024 22:00:11
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