en
Scientific article
Review
English

Radioprotection of craniofacial bone growth

Published inThe Journal of craniofacial surgery, vol. 18, no. 5, p. 995-1000
Publication date2007
Abstract

In this review, the potential of pharmacologic therapy for prevention of radiation-induced bone growth inhibition is discussed. Significant radioprotection using the radioprotector Amifostine has been achieved in animal models of radiation-induced retardation of long and craniofacial bone growth. Moreover, radioprotection in vitro has been achieved in a number of cell lines, including osteoblast-like, endothelial, and fibroblastic. This evidence may support future clinical investigations of radioprotector Amifostine or similar substances for radioprotection of the growing craniofacial skeleton.

Keywords
  • Amifostine/metabolism/pharmacology
  • Animals
  • Bone and Bones/drug effects/radiation effects
  • Cell Line/drug effects/radiation effects
  • Facial Bones/drug effects/growth & development/radiation effects
  • Growth/radiation effects
  • Models, Animal
  • Radiation Injuries, Experimental/prevention & control
  • Radiation Protection/methods
  • Radiation-Protective Agents/metabolism/pharmacology
  • Radiotherapy/adverse effects
Citation (ISO format)
GEVORGYAN, Artur et al. Radioprotection of craniofacial bone growth. In: The Journal of craniofacial surgery, 2007, vol. 18, n° 5, p. 995–1000. doi: 10.1097/scs.0b013e31812f7596
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1049-2275
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