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Radioprotection of craniofacial bone growth

Gevorgyan, Artur
Neligan, Peter C
Pang, Cho Y
Forrest, Christopher R
Published in Journal of Craniofacial Surgery. 2007, vol. 18, no. 5, p. 995-1000
Abstract In this review, the potential of pharmacologic therapy for prevention of radiation-induced bone growth inhibition is discussed. Significant radioprotection using the radioprotector Amifostine has been achieved in animal models of radiation-induced retardation of long and craniofacial bone growth. Moreover, radioprotection in vitro has been achieved in a number of cell lines, including osteoblast-like, endothelial, and fibroblastic. This evidence may support future clinical investigations of radioprotector Amifostine or similar substances for radioprotection of the growing craniofacial skeleton.
Keywords Amifostine/metabolism/pharmacologyAnimalsBone and Bones/drug effects/radiation effectsCell Line/drug effects/radiation effectsFacial Bones/drug effects/growth & development/radiation effectsGrowth/radiation effectsModels, AnimalRadiation Injuries, Experimental/prevention & controlRadiation Protection/methodsRadiation-Protective Agents/metabolism/pharmacologyRadiotherapy/adverse effects
PMID: 17912071
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GEVORGYAN, Artur et al. Radioprotection of craniofacial bone growth. In: Journal of Craniofacial Surgery, 2007, vol. 18, n° 5, p. 995-1000. https://archive-ouverte.unige.ch/unige:44718

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Deposited on : 2015-01-08

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