Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study

Zsiros, József; Brugieres, Laurence; Brock, Penelope; Roebuck, Derek; Maibach, Rudolf; Zimmermann, Arthur; Childs, Margaret; Pariente, Daniele; Laithier, Veronique; Otte, Jean-Bernard; Branchereau, Sophie; Aronson, Daniel; Rangaswami, Arun; Ronghe, Milind; Casanova, Michela; Sullivan, Michael; Morland, Bruce; Czauderna, Piotr; Perilongo, Giorgio

doi:10.1016/S1470-2045(13)70272-9

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Title		Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study
Authors		Zsiros, József Brugieres, Laurence Brock, Penelope Roebuck, Derek Maibach, Rudolf Zimmermann, Arthur Childs, Margaret Pariente, Daniele Laithier, Veronique Otte, Jean-Bernard Branchereau, Sophie Aronson, Daniel Rangaswami, Arun Ronghe, Milind Casanova, Michela Sullivan, Michael Morland, Bruce Czauderna, Piotr Perilongo, Giorgio show all authors [1 - 19]
Collaboration		International childhood liver tumours strategy group With : Ozsahin, Ayse Hulya
Published in		Lancet oncology. 2013, vol. 14, no. 9, p. 834-42
Abstract		The objective of this study was to establish the efficacy and safety of a new treatment regimen consisting of dose-dense cisplatin-based chemotherapy and radical surgery in children with high-risk hepatoblastoma.
Keywords		Adolescent — Antineoplastic Combined Chemotherapy Protocols/therapeutic use — Child — Child, Preschool — Cisplatin/administration & dosage — Combined Modality Therapy — Dose-Response Relationship, Drug — Doxorubicin/administration & dosage — Feasibility Studies — Female — Follow-Up Studies — Hepatectomy — Hepatoblastoma/mortality/pathology/therapy — Humans — Liver Neoplasms/mortality/pathology/therapy — Lung Neoplasms/mortality/secondary/therapy — Male — Prognosis — Prospective Studies — Survival Rate
Identifiers		DOI: 10.1016/S1470-2045(13)70272-9 PMID: 23831416
Full text		Article (Published version) (254 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		Oncologie et hématologie pédiatrique (907)
Citation (ISO format)		ZSIROS, József et al. Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. In: Lancet oncology, 2013, vol. 14, n° 9, p. 834-42. doi: 10.1016/S1470-2045(13)70272-9 https://archive-ouverte.unige.ch/unige:44657